| 2型糖尿病视网膜病变患者细胞间黏附分子1与血浆内皮素1的变化及临床意义 |
| |
| 引用本文： | 徐丽. 2型糖尿病视网膜病变患者细胞间黏附分子1与血浆内皮素1的变化及临床意义[J]. 中国医药指南, 2010, 8(9): 5-5,67 |
| |
| 作者姓名： | 徐丽 |
| |
| 作者单位： | 河南大学第一附属医院检验科,475001 |
| |
| 基金项目： | 河南省科技攻关基金资助项目(0424410102)河南大学第一附属医院检验科 |
| |
| 摘 要： | 目的探讨血浆内皮素1(ET-1)和细胞间黏附分子1(ICAM-1)水平与2型糖尿病视网膜病变(DR)的关系。方法散瞳眼底镜检查及眼底荧光造影检查作为分组金标准,在2型糖尿病患者群中测定93例存在视网膜病变患者分为轻度非增殖性DR(NPDR),中重度NPDR和增殖性DR(PDR)组及138例尚未出现视网膜病变患者(对照组)ET-1和ICAM-1水平。结果ET-1和ICAM-1水平在不同临床分型组间差异有统计学意义;ET-1与病程正相关;多元逐步回归分析显示sICAM-1与ET-1、NPDR、PDR相关。结论检测ICAM-1和ET-1水平可能有助于预测DR的病变程度。
|
| 关 键 词： | 2型糖尿病视网膜病变 细胞间黏附分子1 内皮素1 |
The Changes and Clinical Significance of Intercellular Adhesion Molecule-1 and Plasma Endothelin-1in Patients with Type 2 Diabetic Retinopathy |
| |
| XU Li. The Changes and Clinical Significance of Intercellular Adhesion Molecule-1 and Plasma Endothelin-1in Patients with Type 2 Diabetic Retinopathy[J]. Guide of China Medicine, 2010, 8(9): 5-5,67 |
| |
| Authors: | XU Li |
| |
| Affiliation: | XU Li(Department of Laboratory Medicine,The First Aff iliated Hospital of Henan University,Kaifeng 475001,China) |
| |
| Abstract: | Objective To study the correlation about the levels of plasma endothelin-1(ET-1) and intercellular adhesion molecule-1(ICAM-1) in patients with type 2 diabetic retinopathy(DR).Methods Peripheral blood sample were collected from 241 patients with type 2 diabetes mellitus,93 with retinopathy and 138 without retinopathy as control,diagnosed by ophthalmoscopy and fundus fluorescein angiography.Results The plasma ET-1 and ICAM-1 levels of the DM patients in different clinic classification is statistically signif... |
| |
| Keywords: | Type 2 diabetic retinopathy Intercellular adhesion molecule-1 Endothelin-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
