C-met蛋白在子宫内膜癌中表达的意义

目的探讨肝细胞生长因子 (HGF)受体C met蛋白在子宫内膜癌、子宫内膜非典型增生、子宫增生期内膜中的表达状况与临床分期、组织学分级、肌层浸润、分化程度、淋巴浸润的关系。方法应用免疫组化SP法对 4 1例子宫内膜癌及 17例子宫内膜非典型增生、35例子宫增生期内膜组织中C met表达状况进行检测。结果C met在子宫增生期内膜、子宫内膜非典型增生、子宫内膜癌中的表达 ,差异有显著意义 (P <0 .0 5 ) ,且有逐渐增高的趋势 ;子宫内膜癌中C met表达随组织学分级和临床分期及分化程度的增加而增强 (P <0 .0 5 )。结论C met蛋白对正常内膜细胞的增生、分化有重要的调节作用 ,同时C met在子宫内膜非典型增生及子宫内膜癌中的表达明显逐渐增高 ,推测C met蛋白与子宫内膜癌的发生、发展及预后有关 ,C met蛋白有可能成为判断子宫内膜癌预后的重要指标之一。

Expression of C-met in endometrial carcinoma and clinical significance

Objective To investigate the expression of C-met in endometrial carcinoma, atypical hyperplasia, normal endometrium and collocation with differentiated degree, histological grade, clinical stage, muscle invasiom and lymph gland metastasis of endometrial carcinoma. Methods Expression of C-met was detected in 41 endometrial carcinoma, 17 atypical hyperplasia and 35 normal endometrium by immunohistochemical S-P assay. The relativity between clinico-pathologic feature and prognosis was analyzed. Results The expression of C-met in endometrial carcinoma was higher than that in normal endometrium and atypical hyperplsia (P<0.05). In endometrial carcinoma, the expression of C-met related to differentiated degree, histological grade and clinical stage (P<0.05). Conclusions There was strong expression of C-met in endometrial carcinoma. C-met contributed to cell proliferation, motility and progression of endometrial carcinoma. The expression of C-met might be a useful prognostic factor of endometrial carcinoma.