加用纳洛酮救治急性呼吸窘迫综合征的疗效分析

目的研究综合治疗同时加用纳洛酮（Ｎａｌｏｘｏｅｎ,ＮＬＸ）救治急性呼吸窘迫综合征（ＡＤＲＳ）的疗效。方法将我院同期ＡＤＲＳ患者随机分为综合治疗组（对照组,３１例）,ＮＬＸ治疗组（３３例）,于治疗前、治疗后４小时、１２小时、２４小时分别检测动脉血氧分压（ＰａＯ２）、动脉血氧合指数（ＰａＯ２／ＦｉＯ２）水平。结果ＮＬＸ治疗组及对照组治疗后２４小时,ＰａＯ２值分别为１１．８６±０．６４ｋＰａ,９．１４±０．２６ｋＰａ;ＰａＯ２／ＦｉＯ２值分别为３６．６±１．４ｋＰａ,２２．４±１．７ｋＰａ。两组病死率分别为１８．２％,４５．１％,差异均有显著性（Ｐ＜０．０５）。结论加用ＮＬＸ救治ＡＲＤＳ可快速纠正严重低氧血症,改善肺气体交换功能,明显降低病死率,是临床救治ＡＲＤＳ时一种安全、有效的方法

Analysis on Effect of Naloxone on Acute Respiratory Distress Syndrome

Objective To investigate the effect of Naloxone (NLX) on ARDS during the general treatment.Method 64 cases with ARDS were divided into general treatment group(control group,31 cases) and NLX treated group(33 cases).The level of PaO 2 and PaO 2/FiO 2 were measured before and after treatment on 4h,12h,24h. Results 24h after treating the level of PaO 2 in NLX treated group was significantly higher than that in control group (11.86±0.64kPa,9.14±0.26kPa respectively, P <0.05),the value of PaO 2/FiO 2 was significantly different between the two groups (36.6±1.4kPa,22.4±1.7kPa,respectively, P <0.05).Death rate(18.2%) in NLXtreated group was significantly lower than that(45.1%) in non NLX treated group.Conclusions Adding NLX can obviously correct hypoxemia,improve the air exchange function of lung,and decrease death rate in patients with ARDS.It is a effective and safe method for treating patients with ARDS.