脑梗塞抗心磷脂抗体变化及与血液流变、血脂的关系

目的　探讨抗心磷脂抗体（ ＡＣＡ） 在脑梗塞中的意义及其与多项中风危险因素的关系。方法　５８ 例急性脑梗塞患者于发病１ ～２ 天内以ＥＬＩＳＡ 方法检测血清ＡＣＡ、以ＢＭＥ １ 生物医学处理仪等分别检测血液流变学、血脂指标水平；其中２７ 例于恢复期复查血清ＡＣＡ 水平。结果　急性期ＡＣＡ１９ ．３０ ±１３ ．２７ Ｕ／ ｍｌ，恢复期ＡＣＡ１６ ．２３ ±９ ．５８ Ｕ／ ｍｌ ，两者比较无显著差异（ Ｐ＞ ０ ．０５） ，但均比对照组１０ ．４８ ±４ ．１４ Ｕ／ ｍｌ 明显增高（ Ｐ＜ ０ ．０１） ；患者血液流变学、血脂指标与对照组比较，显示有显著或非常显著差异，且患者ＡＣＡ 水平变化与血液流变学、血脂指标改变呈显著的相关关系（ ｒ ＝ ０ ．０３ ～０ ．６１ ，Ｐ＜ ０ ．０５ ～０ ．０１） 。结论　ＡＣＡ 在脑梗塞的发生中具有重要作用，且在脑梗塞的发病机制中或与多项中风危险因素共同形成了病理效应或促进了这些危险因素在脑梗塞发生中的作用，并提出了对脑梗塞患者恢复期后适当应用抗血小板药物的意义。

Change of Anticadiolopin Antibody and the Relationship between it and Both Hemorrheology and Blood Lipid in Patients with Cerebral Infarction

Objective To study the role of anticadiolopin antibody(ACA) on cerebral infarction and the relationship between it and many stoke risk factors in patients with cerebral infarction(CI).Method ACA were measured by an enzyme linked immunosorbent assay(ELISA) and hemorrheology or blood lipid were examined by BEM 1 biological medical equipment before attack in 58 cases with acute cerebral infarction.27 cases of them were examined for ACA again in recovery period.Results ACA was 19.30±13.27U/ml in acute attack period and it was 16.23±9.58U/ml in recovery period.There was no significant difference between them,but the levels of ACA in patients were significantly higher than those in the control group.The study showed that the changes of the levels of ACA were closely associated with the hemorrheology or blood lipid in patients( r=0.30～0.61,P <0.05～0.01).Conclusions ACA have an important role by producing pathologic effect in conjunction with varies stoke risk factors or promoting the damage role of these risk factors on CI pathogenesis.The research infers that appropriate use of antiplatelet drugs has an important significance in patients with CI in recovery period.