川崎病冠状动脉扩张患儿血小板参数变化及临床意义

目的　探讨川崎病 (KD)冠状动脉扩张患儿血小板参数变化及临床意义。方法 　对川崎病患儿 6 4名及同期健康儿童 2 6名进行血小板计数 (PLT)、平均血小板体积 (MPV)、血小板分布宽度 (PDW)和血小板压积 (PCT)测定 :经心脏彩超检查 ,按照5岁以下儿童冠状动脉内径≥ 3mm为冠状动脉扩张 (CAD)。结果 　KD冠状动脉扩张组患儿急性期和非冠状动脉扩张组患儿急性期PLT较对照组升高有差异 (P <0 0 5) ,PCT较对照组升高有明显差异 (P <0 0 1 ) ,PDW较对照组降低有明显差异 (P<0 0 1 ) ,MPV较对照组降低但无差异 (P >0 0 5) ;KD冠状动脉扩张组急性期与非冠状动脉扩张组急性期比较 ,PLT、MPV、PDW及PCT无差异 (P >0 0 5) ;KD冠状动脉扩张组恢复期MPV较非冠状动脉扩张组恢复期升高有显著差异 (P <0 0 1 ) ;KD冠状动脉扩张组恢复期PLT、PCT较对照组升高有显著差异 (P <0 0 1 ) ,MPV、PDW较对照组降低有明显差异 (P <0 0 1 ) ;KD冠状动脉扩张组恢复期PLT、PCT较急性期升高有显著差异 (P <0 0 1 ) ,MPV、PDW虽有降低但无差异 (P >0 0 5)。结论 　血小板参数可作为判断川崎病患儿病情恢复程度和预测冠状动脉病变及指导临床用药的指标。

Changes and clinical significance of platelet parameter of children with kawasaki disease of coronary artery disease

Objective To study the change and the clinical significance of platelet parameter of children with Kawasaki disease (KD) of coronary artery disease (CAD). Methods Blood platelet counts(PLT)? Medial platelet volume (MPV)? platelet distribution width (PDW)and platelet crit(PCT) were detected by using the blood assay apparatus of model CD-3700 (American). Children were detected by color Doppler,inside diameter of Coronary of Children in 5 year were surpassed 3 mm that was CAD. Results The blood PLT of KD children of CAD in acute period were higher than those of normal children ( P <0.05),PCT were significantly higher than those( P <0.01),PDW were significantly lower than those ( P <0.01). MPV were unchangeable( P >05);PLT?PCT?PDW and MPV were unchangeable compared with those of no CAD in acute period( P >0.05). PLT?PCT of KD children of CAD in recovery period were significantly higher than those of normal children ( P <0.01),MPV,PDW were significantly lower than those ( P <0.01). MPV of KD children of CAD in recovery period were significantly higher than those of no CAD in recovery period( P <0.01);PLT and PCT of KD children of CAD in recovery period were significantly higher than those of CAD in acute period( P <0.01);MPV?PDW were unchangeable( P >05). Conclusion Platelet parameter could be used in judging the recovery degree of KD children,evaluating variety of the patient's coronary artery disease and indicating for the clinical therapeutic drug.