尿碘测定在甲状腺肿瘤筛查中的临床价值

[目的]探讨尿碘(UI)测定在甲状腺肿瘤筛查中的价值。[方法]测定甲状腺良性肿瘤、恶性肿瘤与正常对照组的尿碘水平;另外也测定三组血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、甲状腺球蛋白抗体(TGA)等常用甲状腺功能指标,分析其与甲状腺良恶性肿瘤关系及与尿碘之间的相关性。[结果]恶性甲状腺肿瘤组的尿碘中位数为385.2μg/L,良性甲状腺肿瘤组为240.5μg/L,正常对照组为187.5μg/L,恶性肿瘤组尿碘水平高于良性组及对照组,良性组也高于对照组,均有显著性差异(P<0.05);常用甲状腺功能指标在甲状腺肿瘤组之间无显著性差异(P>0.05),肿瘤组与对照组之间具有显著性差异(P<0.05)。尿碘与TSH之间在恶性甲状腺肿瘤中相关性分析无统计学差异。[结论]尿碘检测有助于高危人群的甲状腺肿瘤疾病的筛查,对甲状腺恶性肿瘤的发生可能起到预警作用。

Clinical Value of Urinary Iodine Determination in Screening for Thyroid Tumor

[Purpose] To explore the clinical value of urinary iodine determination in screening for thyroid tumor. [Methods] The urinary iodine and serum thyroid including TSH, FT3, FT4, TGA in group of thyroid tumor and control group were measured and compared between the 2 groups. [Results] The median urinary iodine was 385.2μg/L in malignant thyroid tumor group, 240.5μg/L in benign tumor group and 187.5μg/L in control group respectively. The concentrations of urine iodine in tumor groups were higher than that in control group（P0.05）, and there was significant difference between malignant tumor group and benign tumor group （P0.05）. No correlation between TSH and the urinary iodine was found. [Conclusions] The determination of urinary iodine probably contributes to screen the thyroid tumor in high-risk Chinese population, and it might play a role of early prediction in thyroid tumor patients.