Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation |
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| Authors: | Tse Anfernee Kai-Wing Wan Chi-Keung Shen Xiao-Ling Yang Mengsu Fong Wang-Fun |
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| Affiliation: | Bioactive Products Research Group, Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, China. |
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| Abstract: | |
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| Keywords: | CHX, cycloheximide EMSA, electrophoretic mobility shift assay GST, glutathione S-transferase ICAM-1, intercellular adhesion molecule-1 IL-8, interleukin-8 IκB, inhibitor subunit of NF-κB IKK, IκB kinase LPS, lipopolysaccharide MCP-1, monocyte chemoattractant protein-1 MMP-9, matrix metalloproteinase-9 NF-κB, nuclear factor-kappa B NIK, NF-κB-inducing kinase PMA, phorbol myristate acetate TNF-α, tumor necrosis factor-alpha TUNEL, terminal deoxynucleotidyltransferase-mediated dUTP mick end labeling |
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