| 广西巴马长寿人群对氧磷酯酶-1基因多态性分析 |
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| 引用本文： | 梁桂云,覃健,何敏,黎湘娟,施礼威,黄倩倩,黄永全,农清清,张志勇.广西巴马长寿人群对氧磷酯酶-1基因多态性分析[J].中国老年学杂志,2012,32(7):1338-1340. |
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| 作者姓名： | 梁桂云 覃健 何敏 黎湘娟 施礼威 黄倩倩 黄永全 农清清 张志勇 |
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| 作者单位： | 1. 广西医科大学公共卫生学院职业卫生与环境卫生教研室,广西 南宁,530021
2. 广西医科大学医学科学实验中心 |
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| 基金项目： | 国家自然科学基金，广西科学基金，广西科学研究与技术开发项目 |
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| 摘 要： | 目的探讨PON1基因Q192R位点在广西巴马地区不同人群中的频率及PON1基因多态性与巴马地区长寿现象的相关性。方法采用TaqMan探针实时荧光PCR技术对广西巴马长寿地区123例长寿老人(年龄90岁以上,长寿组)以及巴马长寿地区138例无长寿史的健康成年人(年龄24～87岁,对照1组)、巴马非长寿地区147例无长寿史的健康成年人(年龄48～89岁,对照2组)和南丹地区144例无长寿史的健康成年人(年龄21～83岁,对照3组)的PON1基因进行基因分型。结果长寿组与各对照组比较,等位基因和基因型分布差异存在统计学意义(P<0.05)。结论该多态性位点与地域有关,与巴马长寿地区的长寿现象是否有关还需进一步验证。
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| 关 键 词： | 长寿 对氧磷酯酶-1 等位基因 多态性 |
Genetic polymorphisms of PON1 in Iongevous people in Bama county of Guangxi province |
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| Institution: | LIANG Gui-Yun,QIN Jian,HE Min,et al.Department of Occupational and Environmental Health,School of Public Health,Guangxi Medical University,Nanning 530021,Guangxi,China |
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| Abstract: | Objective To investigate the correlation between Q192R single nucleotide polymorphisms(SNP) of PON1 gene and human longevity in Bama county.Methods Genotyping of PON1 gene was performed by TaqMan-PCR technique for 123 longevous people(aged 90~110,longevity group) from Bama longevity area,138 healthy cases without long life history from the same area(aged 24~87,control group 1),147 healthy cases without long life history from Bama non-longevity area(aged 48~89,control group 2) and 143 healthy controls without long life history from Nandan(aged 21~83,control group 3).Results There were statistically significant change of some frequencies of alleles and genotypes between longevity group and control group 3(P<0.05).Conclusions These data suggest a modest association between the PON1 gene Q192R and district.It needs a further research to confirm whether there have any relationship between PON1 gene Q192R and longevity phenomenon in Bama longevity area. |
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| Keywords: | Longevity Paraoxonase-1 Allele Polymorphisms |
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