促甲状腺素释放激素对犬肺挫伤合并休克的治疗作用

目的 研究促甲状腺素释放激素（ＴＲＨ）在不依赖容量复苏的条件下对肺挫伤合并失血性休克动物的治疗作用。方法 用ＢＩＭ－Ⅱ型生物撞击机致伤犬，兔右肺中上叶，然后经动脉放血，使平均动脉压（ＭＡＰ）降至８．０ｋＰａ（６０．０ｍｍ Ｈｇ），犬维持３０ｍｉｎ，兔维持６０ｍｉｎ，并给予ＴＲＨ５ｍｇ／ｋｇ静脉注射，观察不同时相点犬血流动力学，磷酸肌酸激酶同工酶（ＣＫ－ＭＢ），呼吸功能，血气，肺分流率，心肺病理形态

Therapeutic effect of thyrotropin releasing hormone on pulmonary contusion and hemorrhagic shock

Objective To study the effect of thyrotropin releasing hormone (TRH) on pulmonary contusion (PC) and hemorrhagic shock in dogs and rabbits. Methods The model of PC was made through the right chest impact by BIM type bioimpact machine and shedding blood from femoral artery. Results 1.TRH had beneficial effect on PC without fluid replacement by enhancing myocardial contractility and improving cardiac function and hemodynamics. 2. TRH could improve pulmonary function and relieve hypoxemia and metabolic acidosis. 3. TRH alone did not cause pulmonary edema and bleeding. 4. NO/ET ratio in plasma and contusion tissue in the TRH group was much higher than that in the control group, but ACE in the TRH group was less than that in the control group. Conclusions TRH has significant therapeutic effect on PC and hemorrhagic shock. TRH therapeutic effect is probably related to its modulating NO/ET ratio of plasma and contusion tissue and protecting endothelial cells of pulmonary blood vessels. Presumably TRH has its advantages in treatment of the patients with PC and shock clinically .