| 姜黄素对S180肉瘤小鼠的抗肿瘤作用及对血清IL-2和IL-12水平影响的研究 |
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| 引用本文： | 张育光,吴声振,刘远亮,刁建新.姜黄素对S180肉瘤小鼠的抗肿瘤作用及对血清IL-2和IL-12水平影响的研究[J].现代食品与药品杂志,2011(12). |
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| 作者姓名： | 张育光 吴声振 刘远亮 刁建新 |
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| 作者单位： | 佛山市中医院药剂科;南方医科大学中医药学院; |
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| 摘 要： | 目的研究姜黄素(curcumin)对S180肉瘤小鼠的作用及机制。方法建立S180肉瘤小鼠模型,给予姜黄素治疗后,观察其抗肿瘤作用及其对小鼠血清IL-2和IL-12水平的影响。结果姜黄素对S180肉瘤有显著抑制作用,可提高肉瘤小鼠的脾脏指数及胸腺指数;能显著提高血清IL-2和IL-12水平。结论姜黄素对S180肉瘤有显著抑制作用,其作用机制可能与升高机体细胞因子,调节小鼠免疫功能有关。
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| 关 键 词： | 姜黄素 IL-2 IL-12 S180肉瘤 |
Study of IL-2 and IL-12 Effects of Curcumin on S180 Tumor-bearing Mice |
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| ZHANG Yu-guang,WU Sheng-zhen,LIU Yuan-liang,DIAO Jian-xin.Study of IL-2 and IL-12 Effects of Curcumin on S180 Tumor-bearing Mice[J].JOurnal of Modern Food and Pharmaceuticals,2011(12). |
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| Authors: | ZHANG Yu-guang WU Sheng-zhen LIU Yuan-liang DIAO Jian-xin |
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| Institution: | ZHANG Yu-guang1,WU Sheng-zhen1,LIU Yuan-liang2,DIAO Jian-xin2(1.Department of Pharmacy,Traditional Chinese Medical Hospital of Foshan,Foshan,Guangdong 528000,China,2.Traditional Chinese Medicine College,Southern Medical University,Guangzhou,Guangdong 510515,China) |
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| Abstract: | Objective To observe the effects of curcumin on S180 tumor-bearing mice.Methods The model of S180 tumor-bearing mice was established.The anti-tumor effects and the levels of serum IL-2 and IL-12 were observed after giving curcumin treatment.Results Curcumin could significantly inhibit the growth of S180 sarcoma,enhance spleen index and thymus index of the tumor-bearing mice and increase IL-2 and IL-12 levels.Conclusion Curcumin can significantly inhibite S180 sarcoma,and its mechanism may be related to the ... |
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| Keywords: | curcumin IL-2 IL-12 S180 sarcoma |
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