中西医结合治疗肾病综合征肾小管功能异常临床观察

目的观察中西医结合疗法治疗肾病综合征肾小管功能异常的临床疗效。方法将60例病例随机分为治疗组和对照组各30例,两组均予西医常规治疗,治疗组同时加用中药滋阴解毒方。两组疗程均为4周,观察临床疗效及治疗前后24h尿蛋白、TG、A／G、Scr、β2-MG的变化情况。结果治疗组和对照组临床疗效差异有统计学意义（P〈0．05）;两组24h尿蛋白、Scr、TG、A／G、血β2-MG、尿β2-MG在治疗后均显著改善（P〈0．05）;组间治疗后比较,24h尿蛋白、尿β2-MG、尿β2-MG清除率差异有统计学意义（P〈0．01）。结论中西医结合疗法治疗肾病综合征可以提高临床疗效,减轻肾小管和肾小球的损伤。

Treatment of Renal Tubule Dysfunction Following Nephrotic Syndrome by Integrative Chinese and Western Medicine

To study the clinical effects of integrative Chinese and western medicine in the treatment of renal tubule dysfunction due to nephrotic syndrome （ NS）. Methods Sixty subjects were divided into two groups： treatment group in which 30 cases were treated with western routine medicine and ＂Ziyin Jiedu Decoction＂ and control group in which 30 cases were treated just with western routine medicine, with a course of four weeks. The levels of 24h urine protein, TG, A/G and Scr were measured by automatic biochemistry analyzer, and β2-MG in blood and urine were measured by isotope detection. Results There was a significant difference in the clinical efficacy between two groups（P 〈0.05） ; the levels of 24h urine protein, TG, A/G, Scr, β2-MG in blood and urine were all improved in both groups（P 〈0.05 ） ; the levels of 24h urine protein, β2-MG in urine and clearance rate of β2-MG were lower in treatment group than in control group （P 〈0.01 ）. Conclusion The integrative Chinese and western medicine can enhance clinical efficacy and relieve the impairments of renal tubule and glomerulus.