偏颇体质2型糖尿病患者中医体质干预研究

目的明确体质干预对偏颇体质2型糖尿病患者的防治作用。方法将100例偏颇体质2型糖尿病患者随机分为干预组50例(脱落3例)和对照组50例(脱落2例),2组维持原有降糖药物治疗,对照组给予糖尿病生活方式指导,干预组同时予纠正偏颇体质的4种措施干预6个月。观察2组干预前后空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、体质量指数(BMI)、血压、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血肌酐(Cr)、尿酸(UA)水平,以及中医体质量表分值、生活质量评价表(SF-36)评分。结果干预组干预后平和质评分和偏颇质总分与本组干预前及对照组干预后比较差异均有统计学意义(P0.05)。干预组干预后FPG、Hb A1c均低于本组干预前及对照组干预后(P0.05)。对照组干预前后FPG、Hb A1c比较差异无统计学意义(P0.05)。干预组干预后BMI、收缩压和舒张压均低于对照组干预后(P0.05),腰围低于对照组,但差异无统计学意义(P0.05);干预组干预后BMI、收缩压和舒张压均低于干预前,但差异无统计学意义(P0.05),对照组干预前后BMI、腰围、血压比较差异均无统计学意义(P0.05)。干预组干预后LDL-C低于对照组干预后(P0.05),2组干预前后TC、TG、HDLC、UA及Cr组间、组内比较差异均无统计学意义(P0.05),干预组干预后LDL-C与本组干预前比较差异无统计学意义(P0.05)。干预组干预后总体健康(GH)、躯体所致角色限制(RP)及生理功能(PF)评分与本组干预前比较差异均有统计学意义(P0.05)。干预组干预后GH、PF评分与对照组干预后比较差异均有统计学意义(P0.05),干预组干预后其余6个维度标准分与对照组比较差异均无统计学意义(P0.05)。结论中医体质干预能够改善2型糖尿病患者的偏颇体质状态,增进平和体质状态,降低血糖水平,改善临床相关异常指标,提高患者生存质量。

Study on the traditional Chinese medicine constitution intervention of type 2 diabetic patients with biased constitution

Objective To clarify the preventive and therapeutic effect of constitution intervention on type 2 diabetic patients with biased constitution.Methods 100 type 2 diabetic patients with biased constitution were randomly divided into intervention group(n =50,3 cases fell off) and control group (n =50,2 cases fell off).The two groups maintained the original hypoglycemic drug treatment.The control group was treated by the guidance of diabetes lifestyle,the intervention group were treated by 4 kinds measures to correct the biased constitution for 6 months.The fasting plasma glucose (FPG),glycosylated hemoglobin (HbA1 c),body mass index (BMI),blood pressure,total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),serum creatinine (Cr) and uric acid (UA),and the scores of 36-item Short-Form Health Survey (SF-36) and traditional Chinese medicine (TCM) constitution scale before and after intervention were observed in two groups.Results There were statistical differences on the scores of peace constitution and biased constitution among before and after intervention in intervention group and after intervention in control group (P ＜ 0.05).The FPG and HbA1c after intervention in intervention group were lower than before intervention and which after intervention in control group (P ＜ 0.05).There was no statistical difference on FPG and HbA1 c between before and after intervention in control group (P ＞ 0.05).The BMI,systolic and diastolic blood pressure after intervention in intervention group were lower than that in control group (P ＜ 0.05),and waist circumference lower than that in control group with no statistical difference (P ＞ 0.05).The BMI,systolic and diastolic blood pressure after intervention were lower than before intervention in group with no statistical difference (P＞ 0.05).There was no statistical difference on BMI,waist circumference and blood pressure between before and after intervention in control group (P ＞ 0.05).The LDL-C after intervention in intervention group was lower than that in control group (P ＜0.05).There was no statistical difference on TC,TG,HDL-C,UA and Cr before and after intervention between-group and intra-group in two groups (P ＞ 0.05).There was no statistical difference on LDL -C between before and after intervention in intervention group (P ＞ 0.05),and with statistical differences on general health (GH),role physical (RP) and physical function(PF) (P ＜ 0.05).There were statistical differences on GH and RF after intervention between the two groups (P ＜ 0.05).There was no statistical difference on the standard scores of the other six dimensions after intervention between the two groups (P ＞ 0.05).Conclusions The intervention of TCM constitution can improve the biased constitution of type 2 diabetes patients,promote the normal constitution,reduce blood glucose,improve clinical relevance abnormal indicators and increase the quality of life.