八珍汤加减联合艾灸对中晚期宫颈癌放化疗患者耐受力、止痛效果和生活质量的影响

目的:探讨加减八珍汤联合艾灸对中晚期宫颈癌放化疗患者耐受力、止痛效果和生活质量的影响。方法:选择2014年2月—2017年4月在河北北方学院附属第二医院就诊的106例中晚期宫颈癌患者,将其按随机数字表分成观察组与对照组,各53例。所有患者均行放化疗治疗,观察组在放化疗基础上联合给予加减八珍汤及艾灸治疗,在完成1个疗程治疗后对两组患者进行短期疗效评估,并于治疗前后比较两组患者的细胞免疫指标、营养指标、疼痛视觉模拟评分(VAS)及卡氏评分(KPS),统计两组不良反应发生情况。结果:观察组总有效率为86.79%,相对于对照组的60.38%明显上升(P0.05)。观察组治疗后CD3~+,CD4~+,CD4~+/CD8~+,NK细胞均较治疗前明显升高(P0.05),但对照组无明显变化;且与对照组同期相比,观察组治疗后以上指标均明显升高(P0.05)。观察组治疗后血清白蛋白、前白蛋白、转铁蛋白水平较治疗前明显上升(P0.05),对照组则明显下降(P0.05);观察组治疗后各项血清营养指标均明显优于对照组(P0.05)。两组治疗1周开始疼痛VAS评分均开始上升,但观察组治疗1,2,4周疼痛VAS评分均明显低于对照组同期(P0.05)。观察组KPS总有效率为84.91%,较对照组的50.94%明显提高(P0.05)。观察组白细胞减少、恶心呕吐发生率分别为35.85%,18.87%,较对照组的56.60%,52.83%相比均明显降低(P0.05)。结论:加减八珍汤联合艾灸治疗可明显提高中晚期宫颈癌放化疗疗效,增强细胞免疫功能,减轻疼痛程度,提高放化疗耐受性,改善患者的生活质量。

Effect of Modified Bazhentang Combined with Moxa-moxibustion on Tolerance, Pain Relief and Life Quality of Patients Receiving Radiotherapy and Chemotherapy for Advanced Cervical Cancer

Objective: To investigate the effect of modified Bazhentang combined with moxa-moxibustion on the tolerance, pain relief and life quality of patients receiving radiotherapy and chemotherapy for advanced cervical cancer. Method: A total of 106 cases of patients with advanced cervical cancer admitted in our hospital from February 2014 to April 2017 were selected and divided into observation group and control group by random number table, with 53 cases in each group. All of the patients were given radiotherapy and chemotherapy. In addition to radiotherapy and chemotherapy, the observation group was also treated with modified Bazhentang combined with moxa-moxibustion. An evaluation on the short-term efficacy of two groups was carried out after one course of treatment. The cellular immune indexes, nutritional indicator, pain visual analogue scale (VAS), Karnofsky scores (KPS) and incidence of adverse reactions were recorded and compared between the two groups. Result: The overall effective rate of observation group was 86.79%, which was higher than 60.38% of control group (P<0.05). After treatment, the CD3⁺, CD4⁺, CD4⁺/CD8⁺, NK cells of observation group remarkably increased compared with those before treatment (P<0.05), but those of control group showed no big difference. What''s more, the above index levels of observation group were higher than those of control group at the same time points after treatment (P<0.05). Compared with those before treatment, serum albumin, prealbumin and transferrin levels of observation group after treatment gained an evident increase (P<0.05), but those of control group showed a big decrease (P<0.05). After treatment, all serum nutritional indicators were better than those of control group (P<0.05). The pain VAS scores of both groups began to rise after 1 week of treatment, but the scores of observation group after 1, 2, 4 weeks of treatment were much lower than those of control group in the same period (P<0.05). The KBS effective rate of observation group was 84.91%, which was significantly higher than 50.94% of control group (P<0.05). The incidences of aleucocytosis and emesis of observation group respectively were 35.85% and 18.87%, which were much lower than 56.60% and 52.83% of control group (P<0.05). Conclusion: In treatment of advanced cervical cancer, modified Bazhentang combined with moxa-moxibustion can significantly improve the effects of radiotherapy and chemotherapy, enhance the immune function, relieve pain, and improve the patients'' chemotherapeutic tolerance of patients and their life quality.