妊娠期糖尿病患者血清IL-17、IL-17R、IL-23水平与肠道菌群的相关性

目的 探讨妊娠期糖尿病(GDM)患者血清白细胞介素-17(IL-17)、白细胞介素-17受体(IL-17R)、IL-23与肠道菌群的相关性.方法 选取2019年1月至2020年1月在该院进行产检的122例孕妇作为研究对象.根据是否合并糖尿病分为GDM组(62例)和糖代谢正常(NGT)组(60例).比较两组孕妇的临床资料...

Correlation between serum IL-17 ,IL-17R and IL-23 levels and intestinal flora in patients with gestational diabetes mellitus

Objective To investigate the relationship between serum interleukin-17(IL-17),IL-17 receptor(IL-17R),IL-23 and intestinal flora in patients with gestational diabetes mellitus(GDM).Methods A total of 122 pregnant women who went to the hospital for antenatal examination from January 2019 to January 2020 were selected as the subjects of the study.They were divided into GDM group(62 cases)and normal glucose tolerance(NGT)group(60 cases)according to whether diabetes was combined.The clinical data,intestinal flora content and serum IL-17,IL-17R,IL-23 level were compared between the two groups,and the correlation analysis of Pearson was carried out.Results The total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FPG)and glycosylated hemoglobin(HbA1c)in the GDM group were significantly higher than those in the NGT group,while high density lipoprotein cholesterol(HDL-C)was significantly lower than that in the NGT group,the differences were statistically significant(P<0.05).The numbers of bifidobacteria and Lactobacillus in the GDM group were significantly lower than those in the NGT group,but the numbers of Enterobacter and Enterococcus in GDM group were significantly higher than those in the NGT group,the differences were statistically significant(P<0.05).IL-17,IL-23 and IL-17R in the GDM group were significantly higher than those in the NGT group,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that IL-17,IL-23 and IL-17R in patients with GDM were positively correlated with enterococci(r=0.630,0.570,0.629,P<0.01),and were positively correlated with Enterobacter(r=0.785,0.843,0.630,P<0.01),while they were negatively correlated with Lactobacillus(r=-0.711,-0.750,-0.614,P<0.01),and were negatively correlated with bifidobacteria(r=-0.811,-0.791,-0.777,P<0.01).Conclusion There is intestinal flora disorder in GDM patients,which may lead to abnormal immune function and changes of inflammatory factor IL-17,IL-17R,IL-23 levels.