DNA甲基化在骨质疏松症中的研究进展

骨质疏松症是以骨微结构退化、强度下降为主要变化的骨骼疾病,常导致骨折的发生.它通常是由骨吸收增加,而骨形成的相应增加不能充分代偿所引起的.骨质疏松症常常由多因素引起,其中遗传因素对于峰值骨量、骨结构以及骨骼恶化和脆性骨折的易感性至关重要.然而,仅遗传因素不足以解释骨质疏松症的发生发展以及脆性骨折的发生.目前表观遗传因素...

Research progress of DNA methylation in osteoporosis

Osteoporosis is a bone disease in which bone microstructure degradation and strength decrease are the main changes, which often lead to fractures. It is usually caused by increased bone resorption, and the corresponding increase in bone formation cannot fully compensate. Osteoporosis is often caused by multiple factors, among which genetic factors are critical to peak bone mass, bone structure, and susceptibility to bone deterioration and fragility fractures. However, genetic factors alone are not enough to explain the occurrence and development of osteoporosis and the occurrence of fragility fractures. At present, epigenetic factors are considered to be closely related to osteoporosis, and it has been confirmed that bone metabolism is regulated by epigenetic mechanisms. DNA methylation, an important component of epigenetics, affects the occurrence and development of osteoporosis by regulating the expression of osteoporosis-related genes. This article reviews the mechanism of DNA methylation on osteoblasts, osteoclasts, and mesenchymal stem cells, and explores the significance and possibility of using DNA methylation as a biomarker for the diagnosis and treatment of osteoporosis.