| Erastin诱导细胞铁死亡在肿瘤治疗中的研究进展 |
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| 引用本文： | 闵楚惟,谷文光. Erastin诱导细胞铁死亡在肿瘤治疗中的研究进展[J]. 中国矫形外科杂志, 2022, 0(1): 48-51 |
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| 作者姓名： | 闵楚惟 谷文光 |
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| 作者单位： | 哈尔滨医科大学附属第一医院骨三科 |
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| 摘 要： | 铁死亡是一种铁依赖性的新型细胞程序性死亡形式,其特征是细胞内致死水平活性氧簇(reactive oxygen species,ROS)以及脂质过氧化物(lipid peroxidation)累积.Erastin是一类经典的铁死亡诱导剂,能够作用于各种分子结构诱导铁死亡的发生,同时在抗肿瘤的应用方面展现广阔的前景.本篇文...
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| 关 键 词： | Erastin 铁死亡 肿瘤治疗 |
Role of erastin in ferroptosis and its application in cancer treatment |
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| MIN Chu-wei,GU Wen-guang. Role of erastin in ferroptosis and its application in cancer treatment[J]. Orthopedic Journal of China, 2022, 0(1): 48-51 |
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| Authors: | MIN Chu-wei GU Wen-guang |
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| Affiliation: | (Department of Orthopaedics,The First Affiliated Hospital,Harbin Medical University,Harbin,Heilongjiang 150001,China) |
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| Abstract: | Ferroptosis is an iron-dependent and newly regulated cell death,which characteristics is excessive accumulation of reactive oxygen species(ROS)and lipid peroxidation.Erastin,a classic ferroptosis inducer,can mediates ferroptosis through a variety of molecules.Meanwhile,erastin shows a promise perspective in anti-tumor application.This article reviews the mechanism of erastin inducing ferroptosis as well as its anti-tumor clinical application. |
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| Keywords: | erastin ferroptosis cancer treatment |
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