~(18)F-FDG PET显像在胰腺癌诊断中的临床应用

目的 :探讨18F FDGPET显像在胰腺癌诊断中的应用价值。方法 :5 4例临床怀疑为胰腺癌的患者均行18F FDGPET显像 ,对显像结果进行目测法及半定量分析 ,并与CT、手术、腹腔镜取病理等进行对比研究。结果 :18F FDGPET显像对胰腺癌诊断的敏感度为 93 % ( 3 8/4 1) ,特异度为 85 % ( 11/13 )。CT对胰腺癌诊断的敏感度为 76% ( 3 1/4 1) ,特异度为 69% ( 9/13 )。18F FDGPET显像发现 7例CT检查未能确定的肝、肺及淋巴结转移 ,同时PET诊断结果使 15例( 2 8% )患者的临床治疗方案得到修正。结论 :18F FDGPET显像对胰腺癌的诊断及临床分期具有较好的临床应用价值。

The clinical application of ~(18) F-FDG PET imaging for diagnosis of pancreas cancer

Objective:To assess the value of 18 F-2-fluoro-2-deoxy-d-glucose (FDG) PET in the diagnosis of pancreas cancer. Methods: 18 F-FDG PET was performed in fifty-four patients who presented with clinical signs of suspected pan- creatic carcinoma.Imaging findings were analysed with semiquantitative method and correlated with other imaging techniques,surgery and pathology by celioiscope.Results:PET had a sensitivity of 93% (38/41) and a specificity of 85% (11/13) in detecting pancreas cancer in 54 patients,while CT had 76% (31/41) and 69% (9/13) respectively. 18 F-FDG PET found metastasis of liver,lung and lymph nodes which were not detected with CT in 7 cases.According to the results of PET scan,the clinical decision of treatment had been corrected in fifteen patients (28%) .Conclusion: 18 F-FDG PET is a very useful modality for diagnosis and clinical staging of pancreas cancer.