抗感染喷剂对切线伤模型SD大鼠创伤修复中bFGF及TGF—β1的影响 |
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引用本文: | 窦群立,刘波,杨锋,钱来军,焦海彬.抗感染喷剂对切线伤模型SD大鼠创伤修复中bFGF及TGF—β1的影响[J].山西中医学院学报,2008,9(4):14-15. |
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作者姓名: | 窦群立 刘波 杨锋 钱来军 焦海彬 |
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作者单位: | [1]陕西中医学院附属医院骨一科,陕西咸阳712000 [2]西安市中医医院椎间盘科,陕西西安710000 [3]山西中医学院第二中医院急诊科,山西太原030024 [4]陕西中医学院,陕西咸阳712046 |
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基金项目: | 陕西省中医管理局资助项目(2005016) |
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摘 要: | 目的:观察抗感染喷剂对SD大鼠软组织切线伤模型肉芽组织中碱性成纤维细胞生长因子(bFGF)、转化生长因子β1(TGF—β1)的影响,探讨抗感染喷剂在创伤修复中的作用。方法:30只大鼠随机分为空白组、湿润烫伤膏对照组(对照组)和抗感染喷剂治疗组(治疗组)。造模后空白组用生理盐水喷洒创面,对照组用湿润烫伤膏涂抹创面,治疗组用抗感染喷剂喷洒创面。应用免疫组化法测定SD大鼠软组织切线伤模型肉芽组织中bFGF、TGF—β1含量的变化。结果:治疗组及对照组肉芽组织中bFGF、TGF—β1水平高于空白组(P〈0.01,P〈O.05)。结论:抗感染喷剂能明显提高bFGF、TGF—β1水平,有促进创伤修复的作用。
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关 键 词: | 抗感染喷剂 创伤修复 bFGF TGF-β1 |
Kangganran Spray on the Expressions of bFGF and TGF-β1 in Granulation Tissue of Skin Wound Model Rats |
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Institution: | Dou Qunli,Liu Bo, Yang Feng, Qian Laijun,Jiao Haibin (Affiliated Hospital of Shaanxi College of TCM,X ianyang Shaanxi 712000) |
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Abstract: | Objective:To observe the effect of Kangganran spray on the expressions of bFGF and TGF- β1 in granulation of skin wound model rats.Method:30 SD rats were randomly divided into Kangganran spray group,Meibao scald paste group and blank group.The expressions of bFGF and TGF- β1 of granulation tissue were detected by immunohistochemistry. Result:Compared with the blank group,the expressions of bFGF and TGF-β1 of granulation tissue were significantly increased in Kangganran spray group and Meibao scald paste group.Conclusion :Kangganran spray can increase expressions of bFGF and TGF-β1and promote the healing of wound. |
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Keywords: | Kangganran spray wound repair bFGF TGF- β1 |
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