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| 静脉注射与13服MTX治疗银屑病临床疗效观察 | |
| 引用本文： | 罗权 李常兴 何玉清 林玲 黄振明 张锡宝. 静脉注射与13服MTX治疗银屑病临床疗效观察[J]. 中国皮肤性病学杂志, 2006, 20(7): 416-417 |
| 作者姓名： | 罗权 李常兴 何玉清 林玲 黄振明 张锡宝 |
| 作者单位： | 广州市皮肤病防治所,广东广州510095 |
| 基金项目： | 广东省医学科学技术研究基金（A2004581） |
| 摘 要： | 目的评价MTX治疗银屑病的两种给药方案的疗效和安全性。方法将68例银屑病患者随机分为两组。口服组：MTX片2．5-5.0mg口服，12 h 1次，1周内连续3次。注射组：MTX注射液7、5～15．0mg静滴，每周1次。两组疗程均为4周。结果口服组与注射组的有效率分别为87．1％和81．1％，有效率比较差异无显著性（P〉0．05）。两种方法治疗前后PASI评分差异无显著性。且口服组较注射组不良反应发生率低。结论MTX治疗银屑病的两种给药方案均有确切疗效，但口服给药副作用更少。 |
| 关 键 词： | 银屑病 甲氨蝶呤 |
| 文章编号： | 1001-7089（2006）07-0416-02 |
| 收稿时间： | 2005-10-08 |
| 修稿时间： | 2005-10-082005-12-31 |
Observation of Clinical Efficacy on Oral or IV MTX in Treatment of Psoriasis |
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| LUO Quan,LI Chang-xing,HE Yu-qing,et al. Observation of Clinical Efficacy on Oral or IV MTX in Treatment of Psoriasis[J]. The Chinese Journal of Dermatovenereology, 2006, 20(7): 416-417 | |
| Authors: | LUO Quan LI Chang-xing HE Yu-qing et al |
| Affiliation: | Guangzhou Institute of Dermatology, Ghangzhou 510095, China |
| Abstract: | Objective To evaluate the efficacy and safety of two ways of methotrexate(MTX) for the treatment of psoriasis.Methods 68 patients with psoriasis were randomly divided into two groups,oral group:MTX 2.5-5.0 mg,tab per 12 h,3 times per week;intravenous group:7.5-15.0 mg,one time every week.Results There were no statistically significant differences between the two groups in terms of clinical efficacy(P>0.05).Adverse effects were lower and mild in the oral group.Conclusion The study indicates that two ways of treatment are effective for psoriasis,and the oral treatment has lower side effects. |
| Keywords: | Psoriasis Methotrexate |
| 本文献已被 CNKI 维普 等数据库收录！ | |