MTDH和VEGF-C在上皮性卵巢癌组织中的表达及其临床病理特征

目的本实验主要研究MTDH和VEGF-C在上皮性卵巢癌组织中的表达情况,及其临床意义和病理特征的相关性,为卵巢恶性肿瘤的发病原因、转移机制提供一定的理论依据。方法 本研究主要通过应用免疫组化SP法检测病变卵巢组织,其中包括19例上皮性卵巢良性肿瘤、25例上皮性卵巢交界性肿瘤、112例上皮性卵巢恶性肿瘤中MTDH和VEGF-C的表达情况;进一步分析上皮性卵巢病变组织的相关临床和病理特征与MTDH和VEGF-C阳性表达率之间的关系。结果 在卵巢癌和卵巢交界性肿瘤中MTDH和VEGF-C的阳性表达率要显著高于卵巢良性肿瘤(P＜0.01)。其中MTDH在上皮性卵巢肿瘤组织中的阳性表达率与患者的年龄和病理类型无统计学意义(P＞0.05),而与组织分级、临床分期、淋巴结转移等有统计学意义(P＜0.05),其中卵巢肿瘤组织的分化程度低、分期晚和淋巴结转移者,MTDH和VEGF-C阳性表达率高。在卵巢恶性肿瘤中,MTDH与VEGF-C阳性表达呈正相关,且与CA125值有密切相关性。结论 MTDH和VEGF-C在上皮性卵巢癌的发生、发展中起重要的作用,可作为判断卵巢癌恶性程度、病情进展的重要指标,联合检测对于指导临床诊断有重要的意义。

Investigation of the expressions of MTDH and VEGF-C and their clinical significance in epithelial ovarian carcinoma

Objective To explore the expressions of MTDH and VEGF-C in epithelial ovarian carcinoma and detect their clinical significance and pathologic parameters.Methods The expressions of MTDH and VEGF-C in epithelial ovarian neoplasm were measured by immunohistochemical method,including 19 cases with benign tumor,25 cases with borderline tumor and 112 cases with malignant tumor.Further analysis was took on the expressions of MTDH and VEGF-C in epithelial ovarian carcinoma to detect the clinical significance and pathologic features.Results The positive expression rate was significantly high in malignant and borderline groups than that in benign group(P＜0.01).The positive expression rate of MTDH is not associated with age and pathologic types(P＞0.05),but with the clinical stage FIGO stage and metastasis(P＜0.05).The positive expression rate of MTDH is high in those low differentiation degree,advanced stage and metastasis cases,and also correlated with the rate of CA125 closely.Conclusion MTDH and VEGF-C play a key role in ovarian cancer occurrence and prosression.The expressions of MTDH and VEGF-C are quite helpful and meaningful in diagnosis and clinicopathologic grade of epithelial ovarian neoplasm.