舒肝解郁胶囊联合阿立哌唑治疗老年精神分裂症阴性症状的临床研究

目的探讨舒肝解郁胶囊联合阿立哌唑治疗老年精神分裂症阴性症状的临床效果。方法选取本院2011年1月～2013年1月老年精神分裂症阴性症状患者84例，随机分为两组，42例患者采用阿立哌唑治疗为对照组，42例患者采用舒肝解郁胶囊联合阿立哌唑治疗为观察组，治疗前后行阳性与阴性症状量表评定，比较两组患者治疗效果和不良反应情况。结果治疗后，两组患者阳性症状评分、阴性症状评分、一般精神病理症状评分、总分均显著降低。观察组阳性症状评分、阴性症状评分、一般精神病理症状评分、总分均明显低于对照组，观察组治疗总有效率明显高于对照组，差异有统计学意义（P〈0．05）。观察组不良反应发生率高于对照组，差异无统计学意义（P〉0．05）。结论舒肝解郁胶囊联合阿立哌唑可明显改善老年精神分裂症阴性症状，提高治愈率，且安全性较高。

Clinical research of Shugan Jieyu capsule and aripiprazole in the treatment of senile schizophrenia negative symptoms

Objective To investigate clinical effect of Shngan Jieyu capsule and aripiprazole in the treatment of senile schizophrenia negative symptoms. Methods 84 elderly patients with schizophrenia negative symptoms were selected in hospital from January 2010 to January 2013, who were randomly divided into two groups.42 patients treated with aripiprazole as control group.42 patients treated with Shugan Jieyu capsule and aripiprazole as observation group. Therapeutic effect and adverse reaction were compared by positive and negative symptom scale before and after treatment between the two groups. Results Positive symptoms score, negative symptoms score, general psychopathology symptoms score, total score in two groups decreased significantly after treatment. Positive symptoms score, negative symptoms score, general psychopathology symptoms score, total score in observation group were significantly lower than control group. Total effective rate in observation group was significantly higher than control group. The difference was significant （P 〈 0.05）.Incidence of adverse reaction in observation group was higher than control group. The difference was not significant （P 〉 0.05）. Conclusion Shugan Jieyu capsule and aripiprazole can improve senile schizophrenia negative symptoms, which can improve cure rate and have higher security.