成都地区291名绝经后女性骨密度与维生素D水平

目的了解成都地区部分绝经后妇女维生素D水平,观察血清25(OH)D3与骨密度、年龄、绝经年龄、体重指数的关系。方法用整群随机抽样方法抽取成都地区291名绝经后女性,平均年龄(63.9±9.7)岁,按每10岁为1个年龄组分组。记录身高、体重、绝经年龄等基本信息,使用双能X线吸收骨密度仪(DXA)测量腰椎2-4椎体(L2-4)、左髋关节股骨颈和全髋骨密度(BMD),用酶联免疫法测定血清25(OH)D3水平。分析绝经后女性骨量及血清25(OH)D3分布情况。结果超过半数的受试者(52.2%)患骨质疏松症,发病率随年龄增加而增高,80岁老年女性发病率达76.47%。血清25(OH)D3水平平均为18.37 ng/mL,维生素D缺乏发生率为68.38%。血清25(OH)D3水平与骨密度、年龄、绝经年龄无关,与BMI呈负相关(P=0.000)。结论成都地区部分绝经后妇女普遍存在维生素D缺乏,绝经后妇女应及时补充维生素D。

Bone mineral density and serum-25-hydroxyvitamin D level of 291 postmenopausal women in Chengdu

Objective To determine the level of serum vitamin D in postmenopausal women in Chengdu , and to explore the corelation with bone mineral density , age, menopausal age and body mass index （BMI）.Methods Using cluster random sampling method , 291 postmenopausal women were recruited and their mean age is 63.9 ＆#177;9.7 years. Height, weight, age, menopausal age and general information were recorded at the same time .Their BMD at lumbar 2-4 （L2-L4）, left femoral neck, total hip were measured by dual-energy X-ray absorptiometry （DXA）.Simultaneously, the serum level of 25（OH）D3 was measured by enzyme-linked immunosorbent assay.To analyze the distribution of bone mass and serum 25（OH）D3 in postmenopausal women, they were divided into five groups according to age .Results More than half （52.2%） postmenopausal women suffered from osteoporosis .Morbidity rate of osteoporosis increased gradually with the age increasing , morbidity rate of elderly women over the age of 80 is the highest , which is 76.47%.The mean values of serum 25（OH）D3 was 18.37 ng/mL in 291 postmenopausal women.The prevalence of vitamin D deficiency is 68.38%in postmenopausal women .No linear correlation relationships was found between serum 25（ OH） D3 and femoral neck BMD, total hip BMD, L2-L4 lumbar spine BMD.Serum 25（OH）D3 level was negatively correlated with BMI （P=0.000 ） .Conclusion Osteoporosis and vitamin D deficiency is very prevalent in postmenopausal women living in Cheng -du.To prevent osteoporotic frature , vitamin D supplementation should be recommended in postmenopausal women .