Prevalence and associated factors of radiographic vertebral fractures in men: Rural population cross-sectional observation study in Japan |
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| Authors: | Masayuki Ichinohe Kanichiro Wada Gentaro Kumagai Sunao Tanaka Toru Asari On Takeda Seiya Ota Kazushige Koyama Kazushige Ihara Shigeyuki Nakaji Yasuyuki Ishibashi |
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| Institution: | 1. Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan;2. Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan;1. Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran;2. College of Medicine, University of Al-Kufa, Kufa, Najaf, Iraq;1. Department of Orthopedics, Sihong People''s Hospital, Suqian, Jiangsu, 223900, PR China;2. Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, 215123, PR China;3. Collaborative Innovation Center of Clinical Immunology Between Soochow University and Sihong People''s Hospital, Jiangsu, PR China;4. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, Jiangsu, 215123, PR China;1. Department of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan;2. Kitasato University School of Medicine, Sagamihara, Japan;1. Department of Othopaedic and Spine Surgery, Fukuoka Children''s Hospital, 5-1-1 Kashii Teriha, Higashi-ku, Fukuoka 812-0017, Japan;2. Department of Othopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan;3. Department of Othopaedic Surgery, Saga Handicapped Children''s Hospital, 2215-27 Kinryu, Kinryu-machi, Saga 849-0906, Japan;1. Department of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan;2. Department of Orthopedic Surgery, Tokyo Women''s Medical University School of Medicine, Shinjuku, Japan;3. Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan;4. Department of Orthopedic Surgery, Chiba Children''s Hospital, Chiba, Japan;5. Funabashi Orthopaedic Sports Medicine & Joint Center, Funabashi, Japan;6. Kitasato University School of Allied Health Science, Sagamihara, Japan;1. Department of Orthopedic, China-Japan Friendship Hospital, Peking Union Medical College, Chinese Academy of Medical College, Beijing, 100853, China;2. Department of Orthopedic, The 980th Hospital of Joint Logistic Support Force of PLA, China;3. Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China |
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| Abstract: | BackgroundOsteoporotic fractures constitute a major health concern in both women and men, particularly with the aging population. Many potential risk factors of vertebral fractures (VFx) have been identified in women, but not in men. Several reports have focused on the quality of life (QOL) of clinically diagnosed VFx, but not much has been reported on quantified QOL scores of incidental radiographic VFx in men. This cross-sectional study aimed to investigate the associated factors and the influence of incident radiographic VFx on QOL of men.MethodsA total of 401 volunteer men aged 40 years or older (40–92 years) participated in this study. The mean age was 60.5 ± 11.8 years. Prevalent VFx were identified on the lateral lumbar spinal radiographs using the semiquantitative method. Bone mineral density, body composition, smoking, alcohol intake, past medical history, Mini-Mental State Examination, grip strength, gait speed, and biochemical markers were examined. QOL was evaluated using the 36-Item Short-Form Health Survey and the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire.ResultsOf the 401 subjects, 35 men (8.7%) had the prevalence of VFx. After adjustment for age, the presence of VFx was significantly associated with IGF-1 (odds ratio 0.985; p = 0.02). QOL scores were not significantly associated with VFx after adjustment for age.ConclusionsIGF-1 is the mediator of growth hormone, and IGF-1 stimulates the proliferation, differentiation, and mineralization of osteoblastic cells. The prevalence of VFx in men was 8.7%, and IGF-1 was significantly lower in the VFx group than in the non-VFx group. |
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