| 抗癌新药——去甲斑蟊素致突变的系列研究 |
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| 引用本文： | 黄念君,林飞,陈世明,曹卫. 抗癌新药——去甲斑蟊素致突变的系列研究[J]. 中国新药与临床杂志, 1986, 0(1) |
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| 作者姓名： | 黄念君 林飞 陈世明 曹卫 |
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| 作者单位： | 卫生部药品生物制品检定所，卫生部药品生物制品检定所，卫生部药品生物制品检定所，卫生部药品生物制品检定所 北京 100050，北京 100050，北京 100050，北京 100050 |
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| 摘 要： | 作者近年按国际标准建立了药物短期致突变系列,这一系列包括用于测定基因(点)突变的Ames试验和测定染色体畸变的中国仓鼠肺细胞试验及微核试验。应用这一系列评价了我国创制的抗癌新药——去甲斑蟊素的致突变性.测试系统还将Ames新菌株、CHL-ED_(50)剂量法则、NIH敏感品系小鼠应用于这一系列。实验显示去甲斑蟊素既不诱发基因(点)突变,也不诱发染色体畸变,这是去甲斑蟊素与一般抗肿瘤制剂之不同点.
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| 关 键 词： | 去甲斑蟊素 致突变 遗传毒性 Ames试验 中国仓鼠肺细胞试验 微核试验 |
Mutagenicity tests of demethyl-cantharidin |
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| HUANG Nian-jun,LIN Fei,CHEN Shi-ming,CAO Wei. Mutagenicity tests of demethyl-cantharidin[J]. Chinese Journal of New Drugs and Clinical Remedies, 1986, 0(1) |
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| Authors: | HUANG Nian-jun LIN Fei CHEN Shi-ming CAO Wei |
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| Abstract: | Demethyl-cantharidin is a new antincoplastic agent first developed in China.Mutagenicity tests were performed: Ames test (including TA92 and TA94 strains of Salmonella typhimurium, gene mutation in vitro), Chinese hamster lung cell test (chromosome aberrations in vitro), and micronucleus test in NIH strain of mice (chromosome aberrations in vivo). Nitroguamid, mitomycin C,daunorubicin, cyclophosphamide, qui-nacrine and aflatoxins were used as positive controls.The results showed that demethyl-cantharidin did not induce gene mutation nor chromosome aberrations. |
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| Keywords: | mutagenicity demethyl cantharidin Ames test Chinese hamster lung cell chromosome aberrations test micronucleus |
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