13-Week Oral Toxicity Study of Captafol in F344/DuCrj Rats

13-Week Oral Toxicity Study of Captafol in F344/DuCrj Rats TAMANO,S., KURATA, Y., SHIBATA, M.-A., TANAKA, H., OGISO, T., AND ITO,N. (1991). Fundarm Appl Toxicol. 17,390–398. Captafolfed at concentrations of 0,0.075, 0.15,0.3, and 0.6% to bothsexes of F344 rats for 13 weeks produced dose-related decreasesin body weight in males and females given 0.15% or higher concentrationsA dose-dependent decrease in urinary pH was observed in malesreceiving 0.3 or 0.6% and in females given 0.15% or higher concentrationsof captafol. The 0.3 and 0.6% doses produced slight increasesin leukocyte count and glutamic-pyruvic transaminase activityin females, along with a mild increase in alkaline phosphataseactivity in the 0.6% case. The liver and kidney-to-body weightratios were increased in both male and female rats. Histopathologicalchanges were observed in the forestomach, liver, and kidney.Squamous cell hyperplasia and edema accompanied by polynuclearleukocyte infiltration and dilation of vessels in the laminapropria were observed in the forestomach of both sexes given0.15% or higher concentrations Oval cell proliferation was apparentaround Glisson's sheath in the livers of females given 0.3 and0.6% captafol. Multifocal appearance of karycytomegaly and tubularcell atypia in the proximal tubules of the kidney was foundin the 0.3 and 0.6% groups of both sexes.