| 蜂胶提取物对肿瘤化疗药物减毒作用的实验与临床研究 |
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| 引用本文： | 高春义,张建,赵跃然,游力,冯进波,田志刚. 蜂胶提取物对肿瘤化疗药物减毒作用的实验与临床研究[J]. 中国生化药物杂志, 2000, 21(2): 90-92 |
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| 作者姓名： | 高春义 张建 赵跃然 游力 冯进波 田志刚 |
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| 作者单位： | 250062,济南,山东省医学科学院基础医学研究所 |
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| 摘 要： | 目的：探讨蜂胶提取物抗肿瘤及减轻化疗药物毒性的作用。方法：通过整体动物实验，将昆明小鼠移植S180肉瘤，观察蜂胶提取物抑制肿瘤作用及与化疗药物合用时的协同及减毒作用。结果：蜂胶提取物的抑瘤率为27．74％，与环磷酸胺合用的抑癌率为50．32％，比单用蜂胶提取物及环磷酸胺分别提高22．58％和9．03％（P＜0．05），并能减轻环磷酰胺所致的骨髓造血功能抑制，使血液白细胞维持在正常水平（P＜0．01）。结论：蜂胶提取物与环磷酰胺合用有协同抗肿瘤作用，并能减轻肿瘤化疗药物的毒副作用。
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| 关 键 词： | 蜂胶提取物 肿瘤 化疗药物 |
| 修稿时间： | 1999-06-11 |
Experimental and Clinical Studies on the Effect of Extract of Propolis on Decreasing the Toxicity of Chemotherapeutant |
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| Gao Chunyi,Zhang Jian,Zhao Yueran,You Li,Feng Jinbo,Tian Zhigang. Experimental and Clinical Studies on the Effect of Extract of Propolis on Decreasing the Toxicity of Chemotherapeutant[J]. Chinese Journal of Biochemical Pharmaceutics, 2000, 21(2): 90-92 |
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| Authors: | Gao Chunyi Zhang Jian Zhao Yueran You Li Feng Jinbo Tian Zhigang |
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| Affiliation: | Gao Chunyi,Zhang Jian,Zhao Yueran,You Li,Feng Jinbo,Tian Zhigang(Institute of Basic Medicine of Shandong Academy of Medical Science Jinan 250062) |
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| Abstract: | Purpose: To study propolis extract antitumor effect and its lowering of the toxicity caused by chemotherapeutant. Methods:Kunming mice transplanted with S180 sarcoma were used to study the inhibition effect of propolis extract on tumor,and its lowering of toxicity caused by synergy with chemotherapeutant. Results:The extract of propolis had certain antineoplasm effect and the inhibition rate of propolis extract on tumor is 27. 74% and when combined with cyclophosphamide, the inhibition rate reached to 5o. 32 %,even antagonized leucocytopenia caused by cyclophosphamide. Conclusion: The extract of propolis could relieve leucocytopenia and thrombocytopenia caused by chemotherapeuant clearly. |
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| Keywords: | Extract of propolis Tumor Chemotherapeutant |
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