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Expression of PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) in human urinary bladder transitional cell carcinoma
Authors:PK Singh  Anupam K Srivastava  D Dalela  SK Rath  MM Goel  MLB Bhatt
Institution:1. Department of Radiotherapy, King George''s Medical University, Lucknow 226003, Uttar Pradesh, India;2. Department of Urology, King George''s Medical University, Lucknow 226003, Uttar Pradesh, India;3. Genotoxicity Laboratory, Division of Toxicology, Central Drug Research Institute (CSIR), Lucknow 226001, Uttar Pradesh , India;4. Department of Pathology, King George''s Medical University, Lucknow 226003, Uttar Pradesh, India;5. Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow 226010, Uttar Pradesh, India
Abstract:The objective of this study was to evaluate the expression pattern of PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) and its clinical significance in human bladder cancer (BC).
Keywords:BC  bladder cancer  PDZ  binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK)  TCC  transitional cell carcinoma  CaUB  carcinoma urinary bladder  CTA  cancer testis antigen  qRT  PCR-quantitative real-time PCR  IHC  immunohistochemistry  FFPE  formalin fixed paraffin-embedded  TURBT  transurethral resection of bladder tumour  WHO  World Health Organization  BCG  Bacillus Calmette-Guerin  BSA  bovine serum albumin  ANCT  adjacent non-cancerous tissue  TAA  tumour associated antigen
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