Smoking effect on chemokines of the human chronic periodontitis |
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| Authors: | Giovanna Ribeiro Souto Celso Martins Queiroz-JuniorFernando Oliveira Costa Ricardo Alves Mesquita |
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| Affiliation: | Department of Oral Surgery and Pathology. School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil |
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| Abstract: | AimEvaluate the effects of smoking on chemokines of the human chronic periodontitis (CP).Materials and methodsGingival samples were obtained from 23 smokers (S) and 20 non-smokers (NS) diagnosed with CP. Periodontal examination was performed. The CCL2, CCL3, CCL5, CCL19, CCL20, and CXCL8 chemokine levels were measured in gingival tissues using enzyme-linked immunosorbent assay. Chemokines were compared between S and NS, and were correlated with the number of cigarettes per day (C/day) and time of the smoking habit in years (SH/years).ResultsCCL3 and CXCL8 of S were significantly smaller than that found in NS subjects, whereas the CCL5 levels increased in the S group. Negative correlations could be observed between CCL19 levels and SH/year.ConclusionSmoking suppresses the immune response which may contribute to an increased susceptibility to periodontal disease in smokers. |
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| Keywords: | CP, chronic periodontitis S, smokers NS, non-smokers C/day, cigarette per day SH/years, smoking habit in years DCs, dendritic cells PD, probing depth CAL, clinical attachment level BOP, bleeding on probing ELISA, enzyme-linked immunosorbent assay |
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