糖尿病患者闪光ERG、OPs和图形VEP的联合检测

探讨糖尿病患者早期F-ERG、OPs和P-VEP的改变情况。方法本实验分三组①观察A组单纯型糖尿病视 网膜病变(DR)患者22例(44只眼)；②观察B组无DR的糖尿病患者42例(84只眼)；③对照组正常受检查32例(64只眼)。所有 受检者均常规检测瞬态F-ERG、OPs和P-VEP，记录各项检测指标。结果与正常组比较①观察A组用F-ERG、OPs和P- VEP检测均发现有显著差异(P＜0.05);②观察B组用F-ERG检测未发现有显著差异(P＞0.05)，用OPs检测发现第1、2子波波 幅明显降低(P＜0.05)，各子波的潜伏期明显延长(P＜0.05)。用P-VEP检测发现P100潜伏期延长(P＜0.05)、波幅降低(P＜ 0.05)。结论用OPs和P-VEP联合检测，可以早期发现糖尿病时视网膜的损害。

APPLICATION OF F - ERG, OPS AND P -VEP TO A COMBINED EXAMINATION OF PATIENTS WITH DIABETES

Objective To study the changes of flighter electroretinogram (F-ERG), oscillatory potentials (Ops) and pattern visual evoked potential (P-VEP) in patients with diabetes mellitus (DM). Methods Three groups were involved in the study. They were Observation Group A including 22 patients (44 eyes) with pure diabetes retinopathy, Observation Group B including 42 diabetic patients (84 eyes) without diabetic retinopathy, and 32 normal subjects as control group. All the subjects received tests by F-ERG, Ops and P-VEP and all the testing indexes were recorded.Results In contrast with the normal group, Group A showed significant difference (P<0.05) when tested by F-ERG, Ops and P-VEP. Between normal group and Group B, F-ERG test revealed no significant difference (P>0.05); OPs test showed that amplitude of OP1 and OP2 were obviously reduced (P<0.05) and the latency of all the OPs was prolonged (P<0.05), whileP-VEP test indicated that the latency of P100 was prolonged and its amplitude was reduced (P<0.05).Conclusion Combined examination by OPs and P-VEP can find diabetic damage to retina in the early period.