The value of serum pro-oxidant/antioxidant balance in the assessment of asphyxia in term neonates |
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| Authors: | Hassan Boskabadi Mohammad Heidarzadeh Amir Avan Majid Ghayour-Mobarhan Gordon A. Ferns |
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| Affiliation: | 1. Department of Pediatrics, Neonatal Research Center, Ghaem Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran,;2. Department of Pediatrics, Community Medicine and Public Health, Tabriz University of Medical Sciences, Tabriz, Iran,;3. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,;4. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, and;5. Division of Medical Education, Brighton and Sussex Medical School, Brighton, UK |
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| Abstract: | ![]()
Objective: Asphyxia is a major cause of disabilities in term-born infants. Here we have explored the value in HIE (hypoxic-ischemic-encephalopathy) of using a combination of serum pro-oxidant/antioxidant balance (PAB) assay for predicting the prognosis of asphyxia.Method: Ninety term neonates with asphyxia were enrolled and followed up for two years. Serum PAB, demographic/biochemical characteristics of mothers, and their neonates were determined. The Denver II test was used to assess outcomes.Results: Of the 90 asphyxiated neonates, 47 (52.2%) had a normal outcome and 43 babies (47.8%) had abnormal outcome. Serum PAB levels in neonates with normal and abnormal outcomes were 17.1?±?9.23 and 48.27?±?41.30 HK, respectively. A combination of HIE intensity and PAB, compared to other indicators, had a higher predictive-value (95.2%) for outcomes in asphyxiated babies.Conclusion: We demonstrate that PAB in combination with HIE grade may have a better predictive value for the prognosis of asphyxiated babies and predicting future neurologic problems in asphyxiated term infants. |
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| Keywords: | Asphyxia hypoxic ischemic encephalopathy newborn PAB balance |
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