红元颗粒抗炎镇痛作用的研究

目的:研究红元颗粒的抗炎镇痛作用。方法:观察其对二甲苯致小鼠耳廓肿胀、冰醋酸致小鼠腹腔毛细血管通透性增高、角叉菜胶致大鼠足跖肿胀、棉球诱导大鼠肉芽肿、冰醋酸致小鼠扭体反应及小鼠热板实验的抑制作用。结果:红元颗粒可以明显抑制二甲苯致小鼠耳廓肿胀(P0.05),降低冰醋酸致小鼠腹腔毛细血管通透性增加(P0.05),减轻角叉菜胶致大鼠足跖肿胀(P0.05),抑制棉球肉芽肿增生(P0.01或P0.05),显著减轻热刺激引起的小鼠疼痛(P0.05);减少小鼠扭体次数(P0.01)。结论:红元颗粒具有显著的抗炎镇痛作用。

Study on Anti-inflammatory and Analgesic Effects of Hongyuan Granule

Objective： To study anti-inflammatory and analgesic effects of Hongyuan granule. Methods： The inhibitory effects were studied by observing xylene-induced swelling ear in mice, acetic acid-induced increase of abdominal capillary permeability in mice, car- rageenin- induced paw edema and cotton ball-induced proliferation of granuloma in rats, hot-induced pain and acetic acid-induced writ- hing in mice. Results： Hongyuan granule significantly reduced swelling ear in mice （ P 〈 0. 05 ）, decreased abdominal capillary permea- bility in mice （ P 〈 0. 05 ）, evidently relieved paw edema in rats （ P 〈 0. 05 ）, and remarkably inhibited proliferation of granuloma in rats （P 〈 0. 01 or P 〈 0. 05 ）, notably alleviated pain induced by hot plate （P 〈 0. 05 ）, as well as obviously reduced the writhing times in mice （ P 〈 0. 05）. Conclusion： Hongyuan granule has obvious anti-inflammatory and analgesic effects.