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| 通窍活血汤预防迟发性脑血管痉挛的实验研究 | |
| 引用本文： | 熊家锐,段传志,王玉斌,王庆宣,成文平,赵刚.通窍活血汤预防迟发性脑血管痉挛的实验研究[J].中国组织工程研究与临床康复,2002,6(6):912. |
| 作者姓名： | 熊家锐 段传志 王玉斌 王庆宣 成文平 赵刚 |
| 作者单位： | 1.151th Hospital of PLA，Anyang 455000，China;2.Zhujiang Hospital，First Military Medical University，Guangzhou 510000，China;3.First Military Medical Univer |
| 摘 要： | Cerebralvasospasm（CVS）isthemostseverecomplicationaftersubarachnoidhemorrhage（SAH），incidencerateisalmost３０％～９０％犤１犦．Andthere＇snospecifictherapeuticstodelayedCVS（DCV）犤２犦，whichisamainreasonleadingtodeathorseveredis－ability．Inthisexperimentalstudy，weuseTongQiaoHuoXueTangtopreventDCVafterSAHinPrimate．１Materialsandmethods１．１Animalgroups，microdialysissystemandSAHmodelDividedmacacaRhesusintotwogroups（fouranimalsineach）．Ac－cordingtothemethodreportedbyRysz… |
| 关 键 词： | subarachnoid hemorrhage delayed cerebral vasospasm Tong Qiao Huo Xue Tang cerebral angiography microdialysis |
| 修稿时间： | 2001年12月18 |
Experimental investigation on the prevention of delayed cerebral vasospasm with Tong Qiao Huo Xue Tang |
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| XIONG Jia rui ,DUAN Chuan zhi ,WANG Yu bin ,WANG Qing xuan ,CHENG Wen ping ,ZHAO Gang.Experimental investigation on the prevention of delayed cerebral vasospasm with Tong Qiao Huo Xue Tang[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2002,6(6):912. | |
| Authors: | XIONG Jia rui DUAN Chuan zhi WANG Yu bin WANG Qing xuan CHENG Wen ping ZHAO Gang |
| Institution: | 1. 151th Hospital of PLA,Anyang 455000,China 2. Zhujiang Hospital,First Military Medical University,Guangzhou 510000,China 3. First Military Medical University, Guangzhou 510000,China |
| Abstract: | Objective To investigate the prevention effects and the physicochemical mechanisms of action of Tong Qiao Huo Xue Tang on delayed cerebral vasospasm(DCD) after subarachnoid hemorrhage(SAH).Methods Macaca cynomolgus were divided into two groups and underwent craniectomy,a semipermeable microdialysis catheter was placed adjacent to right middle cerebral artery (MCA).Therapeutic group were exposed to Tong Qiao Huo Xue Tang and control group to placebo via oral .Results The diameter of proximal MCA in therapeutic group changed slightly on 7th day after operation(P >0.05),whereas it decreased prominently(P< 0.05) in control group with severe vasospasm.OxyHb concentration:There's no significant difference between the two groups on 2nd ～ 5th day(P >0.05),the concentration of therapeutic group(was zero after 8 days) was lower than that of control group (became zero after 12 days) on 6th ～ 8th day(P< 0.05).The peak value of therapeutic group (on 5th day) was lower than that of control group (on 7th day)(P< 0.05).Conclusion Tong Qiao Huo Xue Tang can prevent DCV after SAH effectively and decreasing OxyHb concentration around vessels after SAH maybe the mechanism. |
| Keywords: | subarachnoid hemorrhage delayed cerebral vasospasm Tong Qiao Huo Xue Tang cerebral angiography microdialysis |
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