清痹片对胶原诱导性关节炎大鼠滑膜组织病理学改变的影响

目的:观察清痹片对胶原诱导性关节炎(CIA)大鼠滑膜组织病理形态学的影响。方法:光镜下对CIA大鼠滑膜炎性细胞浸润、滑膜细胞进行评分,观察其组织形态学的改变。结果:CIA模型组大鼠关节滑膜炎细胞浸润明显;而清痹片各给药组及尼美舒利组其病理改变较模型组明显减轻(P<0.05)。模型组大鼠组织形态学改变明显:关节滑膜高度增生,呈乳头状突起,细胞排列不规则,可见大量的炎性细胞浸润等;而各给药组组织形态学改变显著减轻。结论:清痹片能有效减轻CIA大鼠滑膜组织的病理形态学改变,对RA滑膜增生及关节破坏有一定的抑制作用。

The pathological effect of Qingbi tablet on synovium of rat with collagen induced arthritis

Objective: To object the pathomorphological effect of Qingbi tablet on synovium of rats with collagen induced arthritis(CIA).Method: To score for inflammatory cell infiltrate and synovial cell in synovium of CIA rats by light microscope,and to observe the pathology changes.Results: The synovium of joint of model group shows a obvious inflammatory cell infiltrate,compared with model group,the pathological changes were significantly abated in each medication administration team and the Aulin group(P<0.05).The histomorphological changes of model group were also obvious,the synovium of joint hyperplasy excessively,to show a convex papilate,the cell-arrangement is anormal and considerable inflammatory cell infiltrate can be observed;and the histomorphological changes of each medication administration team were significantly abated.Conclusion: Qingbi tablet can effectively abate pathological changes on synovium of rats with CIA,accordingly presume Qingbi tablet have depressant effect on synovium hyperplasia and destruction of joint of RA.