糖调节异常者血尿酸水平与血脂和血压水平的相关性研究

目的 探讨糖调节异常者血尿酸水平与血脂、血压水平的关系.方法 从青岛地区糖尿病和高尿酸血症流行病学调查数据库中选取730例资料完整者进行分析.730例中糖调节异常高尿酸者106例,为A组；糖调节异常正常尿酸者173例,为B组；正常糖耐量高尿酸者103例,为C组；正常糖耐量正常尿酸者348例为D组,记录各组纳入分析者身高、体重、腰围、臀围、血压.采集清晨空腹静脉血,测定血糖、血尿酸、TC、TG、HDL-C等,并行75 g葡萄糖耐量试验测定负荷后2h血糖.结果 ①各组间血尿酸水平由高到低的顺序为A组、C组、B组、D组[ (450±72)、(434±59)、(324±51)、(311±52)μmol/L],差异有统计学意义(P ＜0.05或P＜0.01)；②各组TG、TC、SBP由高到低的顺序为A组、C组、B组、D组[TG:(1.85±0.10)、(1.81 ±0.10)、(1.45±0.10)、(1.43±0.10) mmol/L;TC:(5.72±0.10)、(5.60±0.10)、(5.42±0.10)、(5.12±0.10) mmol/L; SBP:( 142±20)、(138±21)、(135±176)、(125±19)mmHg,1 mmHg =0.133 kPa],差异有统计学意义(P ＜0.05或P＜0.01)；③以糖调节异常者TG、TC为因变量,以年龄、性别、BMI、腰围、血尿酸水平为自变量,进行多元线性回归,血尿酸水平未进入回归方程.以SBP为因变量,以年龄、性别、BMI、腰围、血尿酸水平为自变量,进行多元线性回归,血尿酸水平进入回归方程,差异有统计学意义(P ＜0.05或P＜0.01).结论 糖调节异常高尿酸血症者易合并血脂紊乱和高血压,且高尿酸血症可能是糖调节异常者高血压的独立危险因素,可促进其高血压恶化.

Sreum uric acid concentration, blood pressure and lipids in people with impaired glucose regulation

Objective To investigate the relationship between serum uric acid （SUA） ,blood pressure and lipids in people with impaired glucose regulation. Methods The study had normal glucose tolerance （NGT） （ n = 451 ） and impaired glucose regulation （IGR） （ n = 279 ） patients. All participants had a questionnaire ; levels of serum UA, totalcholesterol （ TC ） , Triglyceride （ TG）, high density lipoprotein cholesterol （ HDL-C ） and fasting blood glucose （FBG）was measured. A standard 75g oral glucose torlerance test was performed in all the participants. Results The trend of SUA change in between-group was significant [ （ A group, C group, B group, D group） ; P 〈 0.05 or P 〈 0.01 ] ; after adjusting age, sex, body mass index （ BMI ）, FBG, fasting blood glucose （ PBG ）, the changing of TC,TG,SBP in between-group was significant [A group, C group, B group, D group TG：（1.85 ±0. 10）, （1.81 ± 0. 10）, （1.45±0. 10）, （1.43 ±0. 10）mmol/L;TC：（5.72 ±0. 10）, （5.60 ±0. 10）, （5.42 ±0. 10）, （5. 12 ± 0. 10） mmol/L;SBP： （ 142± 20）, （ 138 ± 21 ）, （ 135 ±176）, （ 125 ± 19） mm Hg, 1 mm Hg =0. 133 kPa; P 〈0. 05 or P 〈0. 01 ] ; levels of SUA were independent risk factors for hypertension in people with impaired glucose regula- tion, but levels of SUA were unable. Conclusions Hyperuricemia people with impaired glucose regulation can suffer from hypertension and abnormal of blood lipid levels. Hyperuricemia may be an indepentdent risk factor which causes hypertension in people with impaired glucose regulation.