特拉唑嗪联合体外冲击波碎石术治疗输尿管下段结石疗效观察

目的 探讨特拉唑嗪联合体外冲击波碎石术(ESWL)治疗输尿管下段结石的有效性及安全性.方法 112例输尿管下段结石患者完全随机分成2组,对照组56例行ESWL后每天饮水2L;治疗组56例ESWL后口服盐酸特拉唑嗪片4 mg,1次/d.每例患者用药时间不超过2周.ESWL术后2周复查肾-输尿管-膀胱摄影(KUB)与B超,检查结石是否排出,并记录患者发生肾绞痛需要服用镇痛药物的次数.结果 ESWL后2周,对照组排石率为64.3％ (36/56),治疗组为85.7％ (48/56),2组比较差异有统计学意义(P＜0.05).2组因发生肾绞痛而需要镇痛药治疗的比例分别为19.6％(11/56)和7.1％ (4/56),2组比较差异有统计学意义(P＜0.05).治疗组有4例发生头晕.结论 特拉唑嗪能提高输尿管下段结石ESWL后的结石排出率,减少发生肾绞痛的概率,且安全、有效.特拉唑嗪联合ESWL可作为输尿管下段结石的治疗方法之一.

Treatment of lower ureteral stones by terazosin combined extracorporeal shock wave lithotripsy

Objective To evaluate the efficacy and safety of terazosin combined extracorporeal shock wave lithotripsy in the treatment of lower ureteral stone. Methods A total of 112 patients with lower ureter stone were randomly divided into 2 groups. Control group drank water 2 liters in two weeks after ESWL, and treatment group re ceived terazosin （4 mg, once daily） after ESWL. All patients were observed for 2 weeks. After 2 weeks of ESWL, KUB and B ultrasound were checked to judge whether the stone is discharged, and the times of needing to taking the analgesic drugs because of renal colic were recorded. Results During 2 weeks,expulsion of stone was in 36 cases （64. 3 % ） of control group,in 48 cases （85.7%） of treatment group. The difference in expulsion rates between two groups was statistically significant （ P 〈 0.05 ）. Renal colic recurred within 2 weeks and analgesics were used in 11 cases（ 19. 6% ） of control group and in 4 cases（7.1% ） of treatment group with statistically significant（P 〈 0.05）. Conclusions It is demonstrated that terazosin is safe and effective in enhancing stone clearance in patients for lower ureteral stone with ESWL and reducing the probability of occurrence of renal colic.