盐酸多奈哌齐治疗血管源性轻度认知功能障碍的疗效观察

目的:观察盐酸多奈哌齐治疗血管源性轻度认知障碍(vMCI)的疗效。方法:将67例血管源性轻度认知障碍的患者随机分为两组,治疗组33例,在常规治疗的基础上给予盐酸多奈哌齐5 mg,1次/d;对照组34例,给予常规治疗。观察两组治疗前后认知功能[采用简易智力状态检查量表(MMSE)及蒙特利尔认知量表(MoCA)]及日常生活自理能力(ADL)的改善程度。结果:治疗组用药后4周、12周MMSE、MoCA和ADL评分有明显改善,与用药前比较,差异有统计学意义(P<0.01),且和对照组比较,MMSE、ADL评分差异均有统计学意义(P<0.05);对照组在治疗后MMSE评分未见明显改变,与治疗前比较差异无统计学意义(P>0.05),仅ADL在治疗后12周与治疗前比较,差异有统计学意义(P<0.05)。结论:盐酸多奈哌齐治疗血管源性轻度认知障碍疗效确切,对患者认知功能及日常生活能力均有所改善。

Clinical observation on treatment of mild vascular cognitive impairment by donepezil

Objective To evaluate the efficiency of donepezil on mild vascular cognitive impairment.Method Total 67 patients with mild vascular cognitive impairment were randomly divided into two groups：the treatment group（n=33）and the control group（n=34）.Patients in the treatment group were given donepezil（5 mg,once daily） in the foundation of conventional therapy;and the control group was treated by conventional therapy,taking 12 weeks′clinical therapy.The degree of improvement for the cognitive function（MMSE,MoCA） and the ability of taking care of oneself （ADL）were observed.Results After 4 and 12 weeks,the marks of MMSE,MoCA and ADL of the treatment group were significantly improved than that of the control group（P0.01）.The study indicated that the different marks of MMSE,MoCA and ADL had statistical signifcance（P0.05）.Conclusion Donepezil can improve the cognitive function and the ability of taking care of oneself,is effective for mild vascular cognitive impairment.