|
|||||
|
|
| HLA-B27/B7抗原检测在诊断强直性脊柱炎中的临床价值 | |
| 引用本文： | 罗玲,严海燕,罗晓红. HLA-B27/B7抗原检测在诊断强直性脊柱炎中的临床价值[J]. 中国实用医药, 2013, 8(4): 8-9 |
| 作者姓名： | 罗玲 严海燕 罗晓红 |
| 作者单位： | 中山大学孙逸仙纪念医院检验科 |
| 摘 要： | 目的探讨HLA-B27/B7抗原检测在诊断强直性脊柱炎（AS）中的临床价值。方法选取144例门诊及住院高度疑似AS的患者,应用流式细胞仪对其标本进行HLA-B27/B7抗原检测。结果HLA-B27抗原阳性率在青少年人群比较高,且男性显著高于女性,受检的144例患者,HLA-B27抗原阳性率为63.9%,低于确诊为AS的阳性率（91.1%）。HLA-B27抗原检测对诊断AS的灵敏度为91.1%（82/90）,特异度为81.5%（44/54）,正确率为87.5%（126/144）。结论 HLA-B27抗原与AS密切相关,对临床诊断AS很有帮助,用流式细胞术进行检测是较好的方法。 |
| 关 键 词： | 强直性脊柱炎 流式细胞术 HLA-B27 |
The clinical value of HLA-B27/B7 in the diagnosis of ankylosing spondysis |
|
| LUO Ling,YAN Hai-yan,LUO Xiao-hong. The clinical value of HLA-B27/B7 in the diagnosis of ankylosing spondysis[J]. China Practical Medical, 2013, 8(4): 8-9 | |
| Authors: | LUO Ling YAN Hai-yan LUO Xiao-hong |
| Affiliation: | ,Sun YAT-SEN memorial hospital Sun YAT-SEN University,Guangzhou 510120,China |
| Abstract: | Objective To discuss the significance of detection of HLA-B27/B7 in clinical diagnosis of ankylosing spondysis.Methods Flow cytometry was used to detect the HLA-B27/B7 antigen.Results The HLA-B27 positive rate of all patients was 63.9%,which is higher in youths and men,and it was lower than AS patients＇ positive rate（91.1%）.The sensitive of HLA-B27 antigen in diagnosis of AS was 91.1%（82/90）,the specificity was 81.5%（44/54）,and the accuracy was 87.5%（126/144）.Conclusion The HLA-B27 antigen is highly related to the AS,and helpful to the diagnosis of ankylosing spondysis.The flow cytometry is a good method to the detection of HLA-B27 antigen. |
| Keywords: | Flow cytometry Ankylosing spondysis（AS） HLA-B27 |
| 本文献已被 CNKI 维普 等数据库收录！ | |