环—磷酸腺苷在内生致热原性双相热机制中的作用

为确定中枢介质是否参与EP性双相热机制的形成,作者用99只家兔分两部分观察:1.不同浓度EP对热型的影响;2.双相热各期CSF及血浆中cAMP含量的变化。结果显示:1.不同剂量EP静脉注射后引起不同的热型。说明双相热的产生与EP剂量密切相关;2.EP双相热各期CSF中cAMP含量较正常对照显著增高,且与体温的变化基本平行,二者之间有显著的正相关关系。但各期血浆中cAMP含量没有显著变化。说明CSF中增多的cAMP是中枢神经系统自身合成的。作者推论:EP双相热时体温的波动可能与中枢cAMP含量的波动有关。当中枢内cAMP含量波动时,引起体温调定点的上下移动,并进而引起体温的波动而形成双相热。

The action of cAMP in the mechanism of the EP biphasic fever

In order to determine whether the central mediator participates in the mechanism of the EP biphasic fever, the following experiments were carried out: 1. Effect of EP in different doses on the fever pattern; 2. Changes of the cAMP content in CSF and in plasma during the EP biphasic fever. The results obtained demonstrated: 1. After EP were given intravenously in different doses, different fever patterns were produced. 2. The cAMP contents in CSF were increased markedly in every phase of the EP biphasic fever compared with the normal control. These changes of the cAMP content were paralleled and correlated apparently with the body temperature. However, there Were no obvious changes of the cAMP content in plasma during the EP biphasic fever. It demonstrated that cAMP increased in CSF was synthesized and released by CNS for oneself. The authors deduced from above: The wave of body temperature may be related to the changes of cAMP in center during the EP biphasic fever. The fluctuation of cAMP content in the center caused the set-point to move up and down, and further caused the fluctuation of the body temperature and formed the biphasic fever.