慢性阻塞性肺疾病稳定期患者的生存质量及相关因素分析

使用慢性阻塞性肺疾病评估问卷（CAT问卷）对185例稳定期慢性阻塞性肺疾病患者进行CAT评分，使用汉密尔顿抑郁量表（HAMD）测定HAMD评分，并测定患者的肺功能和BMI，详细询问并记录患者是否吸烟及药物使用情况。根据HAMD评分分为抑郁组（65例）和非抑郁组（120例）。结果显示，抑郁组的HAMD评分和CAT评分明显增高，坚持长期家庭氧疗的比例偏低，差异有统计学意义，逐步回归分析发现，CAT评分主要与慢性阻塞性肺疾病全球创议Ⅳ级、HAMD评分相关。提示肺功能严重减退及抑郁对稳定期慢性阻塞性肺疾病患者的生存质量影响较大。

Quality of life and its related factors in patients of stable chronic obstructive pulmonary disease

A total of 185 hospitalized patients with chronic obstructive pulmonary disease （COPD） were recruited. And the questionnaire of COPD Assessment Test （CAT） was used to evaluate the CAT scores and Hamilton Depression Scale to evaluate HAMD scores. Lung function, body mass index, smoking and medication were measured and recorded in details. According to the HAMD scores, 65 cases had depression and 120 cases no depression. Comparing with the no-depression group, the results show that HAMD and CAT scores were higher significantly in the depression group and there was a lower proportion of long-term domiciliary oxygen therapy. According to the logistic regression analysis, the CAT scores were associated with global initiative for chronic obstructive lung disease （GOLD） stages IV and HAMD scores. These results suggest that poor lung function and depression affect greatly the quality of life for stable COPD patients.