| An Experimental Rabbit Model of Rhegmatogenous Retinal Detachment |
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| 作者姓名： | 肖青 曾水清 黄渝凯 王静 李少华 张缨 |
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| 作者单位： | DepartmentofOphthalmology,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430022,China |
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| 摘 要： | An experimental model of rhegmatogenous retinal detachment (RRD) in rabbits was es-tablished to simulate the pathophysiologic condition of human RRD. 24 rabbits were randomly divided into 3 groups and underwent vitrectomy with a vitrector and/or retinotomy with a Charles flute needle, with 12 in group Ⅰ(vitrectomy and retinotomy), 7 in group Ⅱ (retinotomy) and 5 ingroup Ⅲ(vitrectomy). All animals underwent follow-up examinations with direct and indirect ophthalmoscopy and fundus photography 12 h and day 1, 3, 5, 7, 10, 14, 21, and 28 after the proce-dure(s). Retinal changes were recorded. As a result, 10 RRDs were successfully established in group Ⅰ. Direct and indirect ophthalmoscopy and fundus photography demonstrated typical features of RRD. No RRD developed in group Ⅱ and Ⅲ. It was concluded that the experimental rhegmatogenous retinal detachment produced in a rabbit model after vitrectomy with retinotomy in this study was a convenient and reliable one. This RRD model mimicked the typical pathophysiological changes in humans.
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| 关 键 词： | 孔源性视网膜脱离 动物模型 病理形态学 眼外科 |
| 收稿时间： | 2 January 2003 |
An experimental rabbit model of rhegmatogenous retinal detachment |
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| Xiao?Qing,Zeng?Shuiqing,Huang?Yukai,Wang?Jing,Li?Shaohua,Zhang?Ying.An Experimental Rabbit Model of Rhegmatogenous Retinal Detachment[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2004,24(2):181-184. |
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| Authors: | Xiao Qing Zeng Shuiqing Huang Yukai Wang Jing Li Shaohua Zhang Ying |
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| Institution: | Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | Summary An experimental model of rhegmatogenous retinal detachment (RRD) in rabbits was established to simulate the pathophysiologic
condition of human RRD, 24 rabbits were randomly divided into 3 groups and underwent vitrectomy with a vitrector and/or retinotomy
with a Charles flute needle, with 12 in group I (vitrectomy and retinotomy), 7 in group II (retinotomy) and 5 in group III
(vitrectomy). All animals underwent follow-up examinations with direct and indirect ophthalmoscopy and fundus photography
12 h and day 1, 3, 5, 7, 10, 14, 21, and 28 after the procedure(s). Retinal changes were recorded. As a result, 10 RRDs were
successfully established in group I. Direct and indirect ophthalmoscopy and fundus photography demonstrated typical features
of RRD. No RRD developed in group II and III. It was concluded that the experimental rhegmatogenous retinal detachment produced
in a rabbit model after vitrectomy with retinotomy in this study was a convenient and reliable one. This RRD model mimicked
the typical pathophysiological changes in humans.
XIAO Qing, female, born in 1973, M. D., Ph. D. |
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| Keywords: | rhegmatogenous retinal detachment disease model animal rabbits |
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