|
|||||
|
|
| 复方丹参饮对胰岛素抵抗大鼠血清ICAM-1、VCAM-1表达的影响 | |
| 引用本文： | 王清卿,;赵志成,;徐京育. 复方丹参饮对胰岛素抵抗大鼠血清ICAM-1、VCAM-1表达的影响[J]. 中国中医药科技, 2014, 0(4): 389-390 |
| 作者姓名： | 王清卿, 赵志成, 徐京育 |
| 作者单位： | [1]黑龙江中医药大学,哈尔滨150040; [2]黑龙江中医药大学附属第一医院,哈尔滨150040 |
| 基金项目： | 哈尔滨市科技创新人才研究专项资金项目No.RC2011XK00406 |
| 摘 要： | 目的:探讨复方丹参饮对胰岛素抵抗大鼠血清ICAM-1、VCAM-1表达的影响。方法:取健康成年Wistar雄性大鼠60只,随机分为正常对照组、模型对照组、中药预防组、中药治疗组、罗格列酮组,每组12只。采用高脂高糖高胆固醇饮食建立大鼠IR模型;各组大鼠灌胃给药16周后,采用酶免法检测各组大鼠血清中ICAM-1、VCAM-1的含量。结果:与正常对照组比较,除中药预防组,其余各组ICAM-1、VCAM-1含量均增加(P0.05);与模型对照组比较,罗格列酮组及中药预防组、治疗组均能减少ICAM-1、VCAM-1的含量(P0.05)。结论:复方丹参饮可以抑制血清ICAM-1、VCAM-1的表达,防治血管内皮损伤。 |
| 关 键 词： | 胰岛素抵抗 复方丹参饮 血管内皮细胞 细胞间黏附分子-1 血管细胞黏附分子-1 |
Effects of Compound Danshen Decoction on Serum ICAM-1 and VCAM-1 Contents in IR Rats |
|
| Affiliation: | WANG Qing- qing, ZHAO Zhi -cheng2, XU Jing- yu et al ( Heilongjiang University of TCM, Herbin 150040 2First Hospital Atteached to Heilongjiang University of TCM , Harbin 150040) |
| Abstract: | Objective：To investigate the effects of compound Danshen decoction on expressions of serum ICAM-1 and VCAM-1 in rats with IR.Methods：60 Wistar male rats were randomly divided into normal control group,model group,Chinese medicine prevention group,Chinese medicine therapy group and rosiglitazone group,each group contained 12 rats,rats were fed high-fat,high-carbonhydrate and high cholesterol diet,each group were intragastric administration the corresponding medicine for 16 weeks,using ELISA method to determine the content of ICAM-1,VCAM-1 in serum of rats.Results：To compare with normal group,the serum ICAM-1 and VCAM-1 contents in every group were inereased except prevention group （P 〈 0.05）,to compare with model group,the contents of serum ICAM-1 and VCAM-1 were significantly decreased in compound Danshen decoction prevention and treatment group and rosiglitazone group.Conclusion：Compound Danshen decoction can inhibit the expressions of ICAM-1 and VCAM-1 to prevent IR. |
| Keywords: | insulin resistance（IR） compound Danshen decoction vascular endothelial cell intercellular cell adhesion molecule-1 （ICAM-1） vascular cell adhesion molecule-1 （VCAM-1） |
| 本文献已被 CNKI 维普 等数据库收录！ | |