氨溴索在肺挫伤治疗中的作用

目的探讨氨溴索对肺挫伤的治疗作用。方法将2008年5月—2010年5月在我科住院的肺挫伤患者63例随机分为三组,即对照组（仅给一般治疗）、常规剂量组（一般治疗＋常规量氨溴索）和大剂量组（一般治疗＋大剂量氨溴索）各21例。结果治疗后第1天,常规剂量组及大剂量组的PaO2明显高于对照组PaO2（P〈0.01）;治疗后第7天,大剂量组PaO2明显高于常规剂量组及对照组的PaO2（P〈0.01）;治疗后第3天,常规剂量组及大剂量组PaCO2明显低于对照组PaCO2（P〈0.05）;治疗后第3天、第5天,大剂量组SaO2明显高于常规剂量组及对照组的SaO2（P〈0.05）;治疗后第5天、第7天,大剂量组呼吸机辅助呼吸时间明显少于常规剂量组及对照组的辅助呼吸时间。结论对肺挫伤患者早期大剂量应用氨溴索有明显的治疗作用,能显著减轻肺挫伤程度。

Effect of ambroxol in treatment of pulmonary contusion

Objective To investigate the therapeutic action of ambroxol in treatment of pulmonary contusion. Methods Sixtythree patients with pulmonary contusion in our department from May 2008 to May 2010 were randomly divided into three groups. There were 21 patients in the control group （ general treatment only）, the common dose group（ general treatment with common dose of ambroxol） and the large dose group （ general treatment with large dose of amhroxol） respectively. Results PaO2 in the common and large dose groups were significantly higher than that of the control group at the first day post-treatment （ P 〈 0.01 ） ; and PaO2 in the large dose group was significantly higher than that of the control and common groups at the seventh day post-treatment （ P 〈 0.01 ） ;..paco2 in the common and large dose groups were obviously lower than that of the control group at the third day post-treatment （ P 〈 0.05） ; and SaO2 in the large dose groups was obviously higher than that of the control and common group at the third and fifth day post-treatment （ P 〈 0.05） ; time of assisted respiration with breathing machine in the large dose group was less than that of the control and common group at the fifth and seventh day post-treatment. Conclusion There is an obvious therapeutic effect to pulmonary contusion by using of ambroxol in early and full dosage. And it can significantly reduce the degree of injury of lungs.