17β-雌二醇对去卵巢大鼠子宫β-连环素和E-钙粘素蛋白表达的影响

目的探讨“优化”方法在保健食品研发过程中应用。方法在事先调研受试品成分的基础上，采用“优化”设计的方法，利用实验中有共性的程序和个性特点来进行组合式设计的方法，对某受试的保健食品进行缓解疲劳和增强免疫功能的8项指标试验。结果（1）只采用了120只小鼠，获得受试品对小鼠机体8项影响作用的信息。（2）初步判断产品具有缓解疲劳和增强免疫的作用。结论采用实验方案设计和实验指标选定的优化方法，可以用少量的动物获得到研发过程所需的更多的信息。

Application of Refinement Principle in Consumer Health Food Function Accessment

Objective To find out the application value of refinement in consumer health food. Methods Based on the analysis result of contents of the tested samples, eight parameters including fatigue relief and increasing immune function were accessed by adopting ＂refinement＂ methods, in accordance with general procedure and specifically designated principle. Results （1） The data about fatigue relief and increasing immune function were collected by the study carried on 120 mice which is less than common using. （2） Those health food show the good effect on fatigue relief and increasing immune in primary study. Conclusion The refinement method combined with designed requirement method could obtain necessary information with less numbers of laboratory animals.