| 杏仁核毁损对甲基苯丙胺精神分裂症大鼠边缘区多巴胺D2受体的影响 |
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| 引用本文： | 王晓峰,李拴德,刘建新,杨喜民,李鸣,王小亚,张宏兵. 杏仁核毁损对甲基苯丙胺精神分裂症大鼠边缘区多巴胺D2受体的影响[J]. 立体定向和功能性神经外科杂志, 2005, 18(3): 147-150 |
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| 作者姓名： | 王晓峰 李拴德 刘建新 杨喜民 李鸣 王小亚 张宏兵 |
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| 作者单位： | 721004,宝鸡市,解放军第三医院全军精神病外科治疗中心;721004,宝鸡市,解放军第三医院全军精神病外科治疗中心;721004,宝鸡市,解放军第三医院全军精神病外科治疗中心;721004,宝鸡市,解放军第三医院全军精神病外科治疗中心;721004,宝鸡市,解放军第三医院全军精神病外科治疗中心;721004,宝鸡市,解放军第三医院全军精神病外科治疗中心;721004,宝鸡市,解放军第三医院全军精神病外科治疗中心 |
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| 摘 要： | 目的探讨立体定向杏仁核毁损对甲基苯丙胺(methamphetamine,MAP)精神分裂症大鼠脑内边缘区多巴胺D2受体表达的影响.方法40只SD大鼠随机分为对照组、模型组、假手术组和手术组,每组各10只;采用经腹腔注射MAP制备精神分裂症MAP模型,立体定向-射频毁损杏仁核,原位杂交法观察边缘区多巴胺D2受体的表达.结果与对照组比较,模型组及假手术组大鼠边缘区多巴胺D2受体表达有非常显著性差异(P＜0.01);手术组大鼠边缘区多巴胺DA受体阳性细胞数目与对照组比较差异无显著性(P＜0.01).结论杏仁核毁损可以抑制使用MAP而诱发的边缘区D2表达的亢进.
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| 关 键 词： | 精神分裂症 甲基苯丙胺 杏仁核 多巴胺D2受体 |
| 文章编号： | 1008-2425(2005)03-0147-04 |
| 修稿时间： | 2005-03-10 |
The effect of nucleus amygdalae lesion on dopamine receptor 2 in brim region in methamphetamine rats |
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| Wang Xiaofeng,Li Shuande,Liu Jianxin,et al.. The effect of nucleus amygdalae lesion on dopamine receptor 2 in brim region in methamphetamine rats[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2005, 18(3): 147-150 |
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| Authors: | Wang Xiaofeng Li Shuande Liu Jianxin et al. |
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| Affiliation: | Wang Xiaofeng,Li Shuande,Liu Jianxin,et al.Treatment Center of Psychosurgery,PLA,45 Dongfeng Road,Baoji 721004 |
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| Abstract: | Objective To explore the effect of nucleus amygdalae lesion using stereotactic technique on dopamine receptor 2 in brim region in methamphetamine(MAP)rats.Methods 40 Sprague-Dawley rats were randomly divided into four groups:control group,MAP group,MAP and leasion group and MAP and pseudo-lesion group.The nucleus amygdalae were destructed by radio-frequency (RF) using stereotactic technique.Hybridization in situ method was used to experiment the dopamine receptor 2 in brim region in MAP rats.Results Compared with control group,there are much more electropositive cells in brim region in MAP group and MAP and pseudo-lesion group.However,there are fewer electropositive cells in lesion group and control group.Conclusion Lesion of nucleus amygdalae could restrain the haughty expression of dopamine receptor 2 in brim region because methamphetamine employ in rats. |
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| Keywords: | Schizophrenia Methamphetamine Nucleus amygdalae Dopamine receptor 2 |
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