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| 基质金属蛋白酶-9、磷酸化的促血管生成素受体-2在肌肉血管瘤中的表达及意义 | |
| 引用本文： | 王研,亓发芝,顾建英,朱虹光,凌玉琴,符伟国. 基质金属蛋白酶-9、磷酸化的促血管生成素受体-2在肌肉血管瘤中的表达及意义[J]. 中国临床医学, 2007, 14(6): 849-851 |
| 作者姓名： | 王研 亓发芝 顾建英 朱虹光 凌玉琴 符伟国 |
| 作者单位： | 1. 复旦大学附属中山医院整形外科,上海,200032 2. 复旦大学上海医学院病理系,上海,200032 3. 复旦大学附属中山医院血管外科,上海,200032 |
| 摘 要： | 目的:检测肌肉血管瘤血管畸形组织中基质金属蛋白酶-9(MMP-9)及磷酸化的促血管生成素受体(Tie2)的表达,并探讨其意义。方法:收集肌肉血管瘤标本39例、正常颅面部皮下组织标本10例,采用ABC免疫组化染色检测MMP-9、磷酸化的Tie2的表达。结果:MMP-9、磷酸化的Tie2在肌肉血管瘤组织中的阳性表达远高于在正常皮下组织中的表达,差异具有统计学意义(P<0.01);其表达的强度在不同病程、瘤体大小、部位及浸润程度的病例中无明显差异(P>0.05)。结论:MMP-9、磷酸化的Tie2可能参与肌肉血管瘤发生、发展。 |
| 关 键 词： | 肌肉血管瘤 血管畸形 基质金属蛋白酶-9 磷酸化促血管生成素受体-2 |
The Expression and Significance of Matrix Metalloproteinase-9 and Phospho-Tie2 in Intramuscular Hemangioma |
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| WANG Yan,QI Fazhi,GU Jianyin,ZHU Hongguang,LIN Yuqin,FU Weiguo. The Expression and Significance of Matrix Metalloproteinase-9 and Phospho-Tie2 in Intramuscular Hemangioma[J]. Chinese Journal Of Clinical Medicine, 2007, 14(6): 849-851 | |
| Authors: | WANG Yan QI Fazhi GU Jianyin ZHU Hongguang LIN Yuqin FU Weiguo |
| Affiliation: | 1. Departmentof Plastic and Reconstructive Surgery, Department of Vascular Surgery, Zhongshan Hospitial, Fudan University, Shanghai 200032;2. Department of Pathology, Fudan University, School of Medicine, Shanghai 200032 |
| Abstract: | Objective:To investigate the expression and significance of matrix metalloproteinase 9(MMP-9)and Phospho-Tie2 in intramuscular hemangioma.Methods:Specimens of 39 intramuscular hemangiomas and 10 normal subcutaneous tissues in the faces were collected.The ABC immunohistochemical stain was used to investigate the expression of MMP-9 and Phospho-Tie2 in these samples.Results:The expression levels of MMP-9 and Phospho Tie2 were significantly higher in intramuscular heman- giomas than in normal subcutaneous tissues(P<0.01).Their positive intensity had no significant difference statistically among the cases of different courses,locations,dimensions and infiltration degrees.Conclusion:MMP-9 and Phospho-Tie2 may be in- volved in the pathogenesis and development of intramuscular bemangioma. |
| Keywords: | Intramuscular hemangioma Vascular malformation MMP-9 Phospho-Tie2 |
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