| Abstract: | ![]()
The cytotoxic activity of peripheral blood platelets and mononuclears from 82 patients with cancer, 9 with diseases other than cancer, and 18 healthy donors towards a continuous cell line of pulmonary adenocarcinoma was studied. There were no appreciable differences in the killer activity of platelets in cancer patients (32±3.5%), patients with diseases other than cancer (33±8.1%), and healthy donors (30±6.7%). In contrast to platelets, mononuclears of cancer patients possessed a higher cytotoxicity than mononuclears of healthy donors. The cytotoxicity of platelets of cancer patients was found to reliably drop in cases with disseminated metastases and after polychemo-and radiotherapy. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N o 2, pp. 192–195, February, 1996 Presented by N. N. Trapeznikov, Member of the Russian Academy of Medical Sciences |
