脐血干细胞移植治疗失代偿期肝硬化86例疗效观察

目的探讨脐血干细胞移植治疗失代偿期肝硬化的疗效。方法对86例失代偿期肝硬化患者术前常规保肝治疗,采用细胞分离技术自脐带血中提取移植所需要的干细胞,通过肝动脉介入的方法注入肝脏内。干细胞移植后第1、4、10及16周行肝功能检查,第10、16周行肝脏CT检查评价影像学变化。结果术后第1~10周86例患者症状明显改善;术后16周血浆白蛋白水平、凝血酶原活动度较术前均明显提高（P均〈0.01）,谷丙转氨酶、谷草转氨酶较术前均显著降低（P均〈0.05）;术后第16周CT显示肝脏最大截面积较术前明显增加（P〈0.05）。结论脐血干细胞移植治疗可有效修复肝损伤、改善肝功能,提高患者的生存质量。

Umbilical cord blood stem cell transplantation for 86 patients with decompensated cirrhosis

Objective To study the effect of umbilical cord blood stem cell transplantation therapy on decompensated cirrhosis.Methods Before operation,the conventional liver protective therapy were performed on 86 patients of decompensated cirrhosis.The stem cells for transplantation were got from umbilical cord blood using cell isolating technique,and then injected into the patients＇ hepatic artery,leading to the liver.Patients were followed up liver functions on the first week,fourth week,tenth week and sixteenth week after stem cell transplantation respectively,and were followed up liver CT examination on tenth week and sixteenth week.Results Compared with preoperation,the symptoms of all 86 patients improved significantly during the first to tenth weeks.The serum albumin levels and PTA improved greatly on sixteenth week after operation（all P0.01）;ALT and AST significantly decreased（all P0.05）.The liver CT of sixteenth week after operation showed that the RAmax of liver increased significantly campaired with preoperation（P0.05）.Conclusions Umbilical cord blood stem cell transplant therapy could rescue liver injury,improve liver function and enhance the patients＇ quality of life.