| 烹调油烟引发大鼠肺脂质过氧化及其对巨噬细胞膜的损伤作用 |
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| 引用本文： | 叶琳,任淑萍,王春华,杨世杰.烹调油烟引发大鼠肺脂质过氧化及其对巨噬细胞膜的损伤作用[J].中国公共卫生学报,1999(2). |
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| 作者姓名： | 叶琳 任淑萍 王春华 杨世杰 |
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| 作者单位： | 白求恩医科大学预防医学院，白求恩医科大学基础医学院 |
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| 摘 要： | 给大鼠吸入烹调油烟，观察对ＡＭ膜和肺组织细胞的损伤作用以及对肺脂质过氧化作用。结果表明：烹调油烟可以造成大鼠ＡＭ膜流动性明显降低，ＢＡＬＦ中ＬＤＨ、ＡＣＰ和ＡＫＰ不同程度的增加以及肺匀浆中ＬＰＯ显著增加。推测烹调油烟引发脂质过氧化反应可能是造成ＡＭ和肺组织细胞直接损伤的重要机制之一。
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| 关 键 词： | 烹调油烟 脂质过氧化 肺泡巨噬细胞 细胞膜流动性 |
Lipid Peroxidation of Lung and Damage in Alveloar Macrophage Membrane in Rats Induced by Cooking Oil Fume |
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| Authors: | Ye Lin |
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| Institution: | Changchun 130021 |
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| Abstract: | The effects of cooking oil fume on alveolar macrophage (AM) membrane,cells of lung tissue and lipid peroxidation of lung were observed after the rats were exposed to cooking oil fume.The results showed that cooking oil fume could decrease the membrane fluidity of AM and increase the activities of lactate dehydrogenes (LDH),acid phosphatase (ACP) and alkaline phosphatase (AKP) in bronchoalveolar lavage fluid (BALF),and increase the contents of lipid peroxides (LPO) in lung homogenate.The results indicated that cooking oil fume could directly damage AM and cells of lung tissue.One of the main mechanism may be that it can induce lipid peroxidation. |
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| Keywords: | Cooking oil fume Lipid peroxidation Alveolar macrophage Cell membrane fluidity |
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