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Relationship of adrenergic and electrical brain stimulation induced feeding responses
Authors:R Halperin  C L Gatchalian  T J Adachi  J Carter  S F Leibowitz
Affiliation:Mt. Sinai Medical School, Bronx Veterans Administration Hospital and Medical Center and the Rockefeller University, New York, NY USA
Abstract:
Electrical and adrenergic brain stimulation can induce eating in satiated animals. This report explores the interrelationship of brain feeding systems mediating eating in response to norepinephrine and electrical stimulation of the hypothalamus in rats. It was found that simultaneous adrenergic and electrical brain stimulation resulted in a significant increase in food intake as compared to each stimulation condition alone. Furthermore, pharmacological blockade of the alpha-adrenergic receptors in the hypothalamus attenuated feeding in response to adrenergic, but not electrical brain stimulation. Results are interpreted to suggest that these feeding systems are independent at the level of the diencephalon. The role of the vagus nerve as an efferent link through which these brain systems may influence feeding behavior is discussed.
Keywords:Feeding behavior  Hypothalamus  Norepinephrine  Electrical stimulation Paraventricular nucleus  Phentolamin  Adrenergic receptors  Vagal mediation of feeding  Dopamine
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