以宫颈活检为基础评价液基细胞学检查在宫颈癌筛查中的价值

目的:液基细胞学能提高异常细胞的检出率和降低不满意涂片率,因此比传统巴氏涂片更敏感,但还存在争议,我们以病理活检为基础,对AutoCytePREP液基细胞学检查(LCT)在宫颈癌筛查中的价值进行评价。方法:采用横断面研究方法,所有病例来源于我院2004年11月～2006年9月妇科门诊,其中316例病人有完整资料包括细胞学检查(LCT组181例,巴氏涂片组135例)及阴道镜下活检结果,细胞学(LCT或巴氏涂片)采用TBS细胞分类法做出诊断,以≥LSIL为阳性,宫颈活检病理结果为"金标准",以≥CIN2为阳性。结果:LCT的敏感性为0.906,特异性为0.828,巴氏涂片的敏感性为0.710,特异性为0.836。结论:与传统巴氏涂片相比,LCT有较高的敏感性(P<0.05),而两者特异性无明显差别。

Biopsy-based evaluation of liquid-based cytology tests in primary screening for cervical cancer

Objective:Liquid-based cytology tests(LCT)classified more slides as abnormal and decreased unsatisfactory slides,so it is more sensitive than conventional Pap smear test(PAP),but it remains controversial.This paper evaluates the effects of AutoCyte PREP System of LCT in cervical cancer screening based on cervical biopsies.Methods:Cross-sectional study was adopted,patients enrolled were from the gynecological clinics of First Affiliated Hospital of Sun Yat-sen University from November 2004 to September 2006,316 cases had complete information including cytology tests(LCT group 181 cases,PAP group 135 cases)and cervical biopsies directed by Colposcopy.The Bethesda classification system was used in LCT or PAP,classification of ≥LSIL was diagnosed positive,results of cervical biopsy were taken as a "gold standard",biopsy of ≥CIN2 was considered positive.Results:Sensitivity and specificity of LCT were 0.906 and 0.828,0.710 and 0.836 for PAP.Conclusion:Sensitivity of LCT is higher than that of PAP(P<0.05)without significant difference in specificity between them.